What is the recommended dosage of Augmentin (amoxicillin-clavulanate) IV for an adult patient with normal renal function?

Augmentin IV Dosage for Adults with Normal Renal Function

For adults with normal renal function, Augmentin (amoxicillin-clavulanate) IV should be administered at 1.2 g (1000 mg amoxicillin/200 mg clavulanate) every 8 hours, infused over 30-40 minutes. 1

Standard Dosing Regimen

• The recommended dose is 1.2 g IV every 8 hours for most infections in adults with normal renal function 1
• Each 1.2 g dose contains 1000 mg amoxicillin and 200 mg clavulanic acid 1
• The infusion should be administered over 30-40 minutes to minimize infusion-related reactions 1

Dosing Based on Infection Severity

• For mild to moderate infections: 1.2 g IV every 8 hours is appropriate 1
• For severe infections or those involving resistant organisms: The same 1.2 g every 8 hours dosing applies, as this provides adequate serum and tissue concentrations 1
• The total daily dose should not exceed 3.6 g (three doses of 1.2 g) 1

Pharmacokinetic Considerations

• Peak serum concentrations of both amoxicillin and clavulanic acid are achieved shortly after IV infusion completion 1
• In patients with normal renal function, the half-life of amoxicillin is approximately 1-1.5 hours, while clavulanic acid has a shorter half-life of approximately 1 hour 1
• The 8-hour dosing interval maintains therapeutic concentrations above the MIC for most susceptible pathogens 1

Common Pitfalls and Caveats

• Do not confuse IV and oral formulations: The IV formulation has different dosing than oral Augmentin, which is typically 375-625 mg orally three times daily 2, 3
• Infusion rate matters: Rapid IV push is not recommended; always infuse over 30-40 minutes to reduce the risk of adverse reactions 1
• Renal function monitoring: Even in patients with initially normal renal function, monitor for changes during treatment, as dose adjustment is required if creatinine clearance falls below 30 mL/min 1
• Duration of therapy: Treatment duration depends on the infection type and clinical response, typically ranging from 5-14 days 2

Special Clinical Scenarios

• Perioperative prophylaxis: For surgical procedures, a single 1.2 g IV dose may be given 30-60 minutes before incision, with repeat dosing every 8 hours if the procedure is prolonged 2
• Urinary tract infections: The standard 1.2 g every 8 hours dosing is effective, with treatment duration of 7-12 days depending on severity 2
• Respiratory tract infections: The same dosing regimen applies, with typical treatment courses of 7-10 days 4