Can Chymoral Forte Be Used Three Times Daily?
Yes, Chymoral Forte (alpha-chymotrypsin) can be taken three times daily, as this is the standard dosing regimen explicitly stated in the FDA-approved labeling for adults and children 12 years and older. 1
FDA-Approved Dosing
The official prescribing information for Chymoral Forte specifies the following dosing schedule 1:
For Adults and Children ≥12 years:
- As a relaxant: 1-2 caplets with water as needed three times daily 1
- For occasional sleeplessness: 1-3 caplets taken 30-60 minutes before bedtime 1
For Children 6-12 years:
- As a relaxant: 1 caplet with water as needed three times daily 1
- For occasional sleeplessness: 1-2 caplets taken 30-60 minutes before bedtime 1
Clinical Context and Timing
The three-times-daily dosing regimen is designed to maintain therapeutic levels throughout the day for its anti-inflammatory and anti-edema effects 1. This dosing frequency aligns with the pharmacokinetic profile of alpha-chymotrypsin, which demonstrates maximum fibrinolytic activity 6-9 hours after administration 2.
Important Safety Considerations
While three-times-daily dosing is approved, clinicians should be aware that:
- Alpha-chymotrypsin has fibrinolytic activity that affects hemostasis, so it should be used with appropriate monitoring for postoperative edema and hematoma prophylaxis 2
- The medication should be taken with water as directed 1
- Dosing should be adjusted based on age group as specified in the labeling 1
The three-times-daily regimen is the standard, FDA-approved dosing schedule for Chymoral Forte when used as a relaxant in appropriate patient populations. 1