What is the cause of severe health anxiety, left upper quadrant abdominal fullness (LUQ fullness) that worsens with sitting, palpable lymph nodes in the left elbow, and fatigue for 10 months?

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Differential Diagnosis for Severe Health Anxiety and Associated Symptoms

Single Most Likely Diagnosis

  • Irritable Bowel Syndrome (IBS): Given the fullness under the left ribs that worsens with sitting, this could be indicative of gastrointestinal issues. IBS is a common condition that can cause abdominal discomfort, bloating, and changes in bowel habits, which might be exacerbated by anxiety. The palpable lymph nodes could be reactive, and fatigue is a common symptom in both IBS and anxiety disorders.

Other Likely Diagnoses

  • Gastroesophageal Reflux Disease (GERD): The symptom of fullness under the left ribs, especially when sitting, could be related to GERD, where stomach acid flows back into the esophagus, causing discomfort.
  • Anxiety Disorder: While mentioned as a given, it's essential to consider that severe health anxiety itself can exacerbate or mimic physical symptoms, including fatigue and potentially contributing to the perception of other symptoms.
  • Hypochondriasis: Now more commonly referred to under the umbrella of Illness Anxiety Disorder, this condition involves excessive worry about having a serious illness despite medical reassurance, which could explain the severe health anxiety.

Do Not Miss Diagnoses

  • Lymphoma: Although less likely, the presence of palpable lymph nodes, particularly if they are persistent or growing, necessitates consideration of lymphoma. Early detection is crucial for effective treatment.
  • Gastric or Pancreatic Cancer: These cancers can present with vague abdominal symptoms, including fullness or discomfort under the ribs, and fatigue. Early diagnosis significantly improves prognosis.
  • Splenomegaly: An enlarged spleen could cause fullness under the left ribs and could be due to various causes, including infections, liver diseases, or blood disorders.

Rare Diagnoses

  • Splenosis: If there's a history of trauma, splenosis (ectopic splenic tissue) could cause abdominal symptoms and might be considered if other diagnoses are ruled out.
  • Castleman Disease: A rare disorder that involves an overgrowth of cells in the body's lymph nodes, which could explain the palpable lymph nodes and systemic symptoms like fatigue.
  • Ehlers-Danlos Syndrome: A group of disorders that affect connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues, which could potentially explain a variety of symptoms including gastrointestinal issues and fatigue, though it's a stretch without other specific signs.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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