Is using 500IU of Human Chorionic Gonadotropin (HCG) daily for 10 days too aggressive for a 6-year Testosterone Replacement Therapy (TRT) patient looking to discontinue treatment and restart natural testosterone production?

HCG Protocol After Long-Term TRT Discontinuation

Your proposed protocol of 500 IU HCG daily for 10 days is not supported by evidence-based guidelines and significantly exceeds recommended dosing for restarting natural testosterone production after TRT cessation. 1

Why Your Protocol Is Too Aggressive

The dose is excessive and the duration is insufficient. Current evidence demonstrates that:

• Lower doses are effective: Studies show that 250-500 IU of hCG administered 2-3 times weekly (not daily) successfully maintains intratesticular testosterone production and can restore spermatogenesis 2
• Your daily dosing equals 3,500 IU weekly (500 IU × 7 days), which is 2-7 times higher than the typical therapeutic range of 500-2,500 IU per week used for hypogonadotropic hypogonadism 1
• Recovery takes months, not days: After 6 years of TRT-induced suppression, the hypothalamic-pituitary-gonadal axis requires prolonged stimulation—typically 3-6 months or longer—not just 10 days 1

Evidence-Based Recovery Protocol

Phase 1: Initial HCG Monotherapy (3-6 months minimum)

• Start with 500 IU hCG subcutaneously 3 times weekly (Monday/Wednesday/Friday schedule) 1, 3
• Alternative dosing: 1,000-1,500 IU every other day has been used successfully 4
• This provides 1,500 IU weekly, which research shows maintains intratesticular testosterone in the normal range 2

Phase 2: Monitoring and Adjustment

• Check testosterone levels at 2-3 months to assess testicular response 5
• Measure LH and FSH to confirm they remain suppressed initially, then gradually recover 1
• If testosterone remains low after 3 months on hCG alone, consider adding FSH 75-150 IU three times weekly 1

Phase 3: Transition Off HCG

• Continue hCG for minimum 3-6 months before attempting discontinuation 1, 3
• After 6 years of suppression, recovery may take 6-12 months or longer 1
• Some men remain azoospermic for months to years after TRT cessation, even with hCG therapy 1

Critical Pitfalls to Avoid

Do not use supraphysiologic hCG doses: Doses above 2,500 IU per injection can cause Leydig cell desensitization, paradoxically reducing testosterone production 4

Do not expect rapid recovery: Your 10-day protocol reflects a fundamental misunderstanding of HPG axis recovery kinetics. After 6 years of exogenous testosterone, your pituitary gonadotrophs are profoundly suppressed and require months of stimulation to regain normal function 1

Do not stop hCG prematurely: Discontinuing after just 10 days will leave you with suppressed LH/FSH and inadequate intratesticular testosterone, resulting in symptomatic hypogonadism 2

Alternative Consideration: Selective Estrogen Receptor Modulators

If fertility is not your primary concern, consider:

• Clomiphene citrate 25-50 mg daily or enclomiphene 12.5-25 mg daily as alternatives to hCG 1
• These stimulate endogenous LH/FSH production rather than replacing it
• May be more physiologic for long-term HPG axis recovery
• Typically used for 3-6 months minimum 1

Realistic Expectations

After 6 years of TRT, complete recovery is not guaranteed:

• Approximately 67-90% of men eventually recover spermatogenesis after TRT cessation, but this can take 6-24 months 1
• Some men never fully recover baseline testosterone production 1
• Older age and longer duration of TRT (like your 6 years) predict slower and less complete recovery 1

Your best approach: Start with 500 IU hCG three times weekly, plan for 6-12 months of therapy, and work with a reproductive endocrinologist or urologist experienced in male fertility to monitor your recovery 1, 5