From the Research
Yes, there are peptides that can help with damaged nerves, with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) being potential therapeutic options to increase neural repair and recovery. These peptides have demonstrated the ability to improve functional recovery in preclinical and to a lesser extent clinical studies, as shown in a 2022 study published in Neural Plasticity 1.
Key Peptides for Nerve Repair
- BDNF and NGF serve as key mediators of neural plasticity and functional recovery, promoting neuroprotection and regeneration.
- Other peptides like BPC-157 and TB-500 have also shown promise in nerve regeneration and repair, although their use is still being researched and they are not FDA-approved for this specific purpose.
Mechanism of Action
- These peptides work by promoting angiogenesis, reducing inflammation, and accelerating tissue healing processes, which may help increase nerve growth factor expression and support the structural integrity of nerve cells.
- Direct and indirect methods to increase levels of neurotrophic factors in animal models have been successful in improving postinjury outcome measures, as noted in a 2022 study published in the International Journal of Molecular Sciences 2.
Clinical Use
- Peptides like BPC-157 and TB-500 are commonly used at specific doses and administration schedules, such as 250-500mcg once or twice daily for BPC-157 and 2-2.5mg twice weekly for TB-500, followed by a maintenance phase.
- Cerebrolysin, a peptide mixture, is used clinically in some countries at doses of 5-30ml daily for 10-20 days to support neurological recovery.
Importance of Early Intervention
- Early intervention is crucial in the management of nerve injuries, as changes in the nerve, neuromuscular junction, and muscle can become irreversible approximately 18 to 24 months following denervation, as highlighted in a 2019 study published in The Journal of Trauma and Acute Care Surgery 3.
- A 2020 study published in the International Journal of Biological Sciences 4 emphasizes the need for optimal treatments to achieve complete functional recovery, and plant-derived compounds are being explored for their potential remedial effects.