From the Research
The most effective treatment for angular cheilitis is a combination of 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV) ointment, due to its broad spectrum of activity against dermatophytes and bacteria, as well as its anti-inflammatory properties. This treatment approach is based on a recent narrative review and clinical experience published in 2020 1. The review highlights the limited scientific evidence supporting the use of antifungals as the first-line treatment for angular cheilitis, with only two RCTs published between the 1970s and 1980s.
Key considerations for treating angular cheilitis include:
- Identifying and addressing underlying causes, such as nutritional deficiencies or occlusal issues
- Maintaining good oral hygiene and keeping the affected area clean and dry
- Using topical treatments, such as the combination of ISN and DFV, to target both fungal and bacterial components
- Considering alternative treatments, such as photodynamic therapy or B-vitamin supplementation, in cases where standard treatments are ineffective
It is essential to note that further research is needed to assess the effectiveness of different treatments for angular cheilitis, as current evidence is largely based on case reports and small-scale studies 1. However, based on the available evidence, the combination of ISN and DFV ointment appears to be a promising treatment option for angular cheilitis.