From the Guidelines
Prednisone can be taken with or without food, but it is recommended to take it with food when possible to reduce stomach irritation and decrease the risk of gastrointestinal side effects. According to a clinical practice guideline published in the BMJ in 2018 1, corticosteroids, including prednisone, can be given with or without food when taken orally, but it is suggested to take them with food when possible. This is because prednisone is a corticosteroid that can irritate the stomach lining when in direct contact with it.
Some studies have shown that taking prednisone with food can reduce the risk of stomach ulcers, indigestion, and other digestive problems. For example, a study published in the Journal of the National Comprehensive Cancer Network in 2019 1 found that taking abiraterone with prednisone at 250 mg/day after a low-fat breakfast was effective and reduced financial toxicity. However, it is essential to note that food can impact the absorption of prednisone unpredictably, and side effects should be monitored.
- Key points to consider:
- Prednisone can be taken with or without food
- Taking prednisone with food can reduce stomach irritation and decrease the risk of gastrointestinal side effects
- Food can impact the absorption of prednisone unpredictably, and side effects should be monitored
- It is recommended to follow the doctor's specific instructions regarding the prednisone regimen, including dosage and timing.
- In general, it is best to take prednisone with food or milk to minimize the risk of gastrointestinal side effects, but the decision to take it with or without food should be made on an individual basis, taking into account the patient's specific needs and medical history, as well as the guidance of a healthcare professional.
From the FDA Drug Label
Gastric irritation may be reduced if taken before, during, or immediately after meals or with food or milk. The FDA recommends taking prednisone with food or milk to reduce gastric irritation.
- It is not explicitly stated that prednisone cannot be taken on an empty stomach, but taking it with food or milk is recommended to minimize gastric irritation 2, 2.
- Morning administration is also recommended, prior to 9 am, to suppress adrenocorticoid activity the least.
From the Research
Taking Prednisone
- There are no research papers to assist in answering this question about taking prednisone on an empty stomach or fasting, as the provided studies focus on proton pump inhibitors and antiemetic drugs.
- The studies 3, 4 do not mention prednisone or its administration in relation to fasting.
- The information provided in the studies 3, 4 discusses the adverse effects of proton pump inhibitors and the use of antiemetic drugs, respectively, but does not address the topic of taking prednisone while fasting.