What is the most common cause of palpable left elbow lymphadenopathy (lymph nodes) and a feeling of fullness under the left costal margin (ribs) that worsens when sitting in a 31-year-old female?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for 31 Year Old Female with Palpable Left Elbow Lymph Nodes and Feeling of Fullness Under Left Ribs

  • Single Most Likely Diagnosis
    • Gastritis or Gastroesophageal Reflux Disease (GERD): The feeling of fullness under the left ribs that worsens when sitting could be related to gastric issues, as sitting can increase pressure on the stomach. Palpable lymph nodes in the elbow could be reactive, which is a common response to infection or inflammation, including gastritis.
  • Other Likely Diagnoses
    • Viral Hepatitis: Hepatitis can cause lymphadenopathy (enlarged lymph nodes) and discomfort in the upper abdomen, which might be perceived as fullness under the ribs. The symptoms could be exacerbated by positions that increase pressure on the liver or spleen.
    • Splenomegaly (Enlarged Spleen): An enlarged spleen can cause a feeling of fullness under the left ribs and can be associated with lymphadenopathy. Splenomegaly can result from various conditions, including infections, liver diseases, and blood disorders.
    • Lymphoma: Although less common, lymphoma should be considered, especially if the lymphadenopathy is persistent and accompanied by systemic symptoms like fever, night sweats, or weight loss.
  • Do Not Miss Diagnoses
    • Abdominal Lymphoma: This is a critical diagnosis not to miss, as it can present with abdominal fullness and lymphadenopathy. Early detection is crucial for effective treatment.
    • Splenetic Rupture or Infarct: These conditions are emergencies that can cause severe abdominal pain and might be associated with lymphadenopathy if there's an underlying condition like lymphoma or severe infection.
    • Tuberculosis (TB): TB can cause lymphadenopathy and abdominal symptoms, including fullness. It's a critical diagnosis to consider, especially in areas where TB is prevalent or in individuals with risk factors.
  • Rare Diagnoses
    • Castleman Disease: A rare disorder that involves an overgrowth of cells in the body's lymph nodes, which can cause lymphadenopathy and might be associated with systemic symptoms.
    • Primary Sclerosing Cholangitis: A rare disease that leads to scarring, inflammation, and destruction of the bile ducts, which could potentially cause abdominal discomfort and lymphadenopathy, although it's less directly related to the symptoms described.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.