Differential Diagnosis
- Single most likely diagnosis
- E) Stevens-Johnson syndrome: This condition is characterized by a widespread, painful rash, fever, and mucous membrane involvement, including conjunctival erythema, photophobia, and oral ulcers. The recent initiation of amoxicillin therapy is a potential trigger for Stevens-Johnson syndrome, which is a severe skin and mucous membrane disorder often caused by an adverse reaction to medications.
- Other Likely diagnoses
- A) Mucocutaneous lymph node syndrome (Kawasaki disease): Although Kawasaki disease typically presents with fever, rash, conjunctivitis, and lymphadenopathy, the presence of oral ulcers and the specific pattern of the rash might not fully align with the classic presentation of Kawasaki disease. However, it remains a consideration due to the overlap of symptoms.
- C) Serum sickness: This condition can occur after the administration of certain medications, including antibiotics like amoxicillin, and is characterized by fever, rash, and lymphadenopathy. However, the mucous membrane involvement (e.g., conjunctival erythema, oral ulcers) is more suggestive of Stevens-Johnson syndrome.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- D) Staphylococcal scalded-skin syndrome: Although less likely given the clinical presentation, this condition is life-threatening and should not be missed. It typically presents with widespread skin exfoliation and is more common in younger children.
- B) Scarlet fever: While scarlet fever can cause a rash and fever, the presence of conjunctival erythema, photophobia, and oral ulcers is not typical for this condition. However, given its potential severity, especially if caused by a resistant strain of Group A Streptococcus, it should be considered to ensure appropriate antibiotic coverage.
- Rare diagnoses
- Other rare conditions that could potentially present with similar symptoms include autoimmune disorders (e.g., erythema multiforme) or reactions to other medications. However, given the information provided, these would be less likely and are not listed among the options.