What are the differential diagnoses for a patient presenting with acute abdominal pain, nausea, vomiting, and diarrhea?

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Last updated: February 14, 2025View editorial policy

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Differential Diagnoses for Abdominal Pain with Nausea, Vomiting, and Diarrhea

Single Most Likely Diagnosis

  • Gastroenteritis: This is the most likely diagnosis given the combination of abdominal pain, nausea, vomiting, and diarrhea. Gastroenteritis, often caused by viral or bacterial infections, is a common condition that matches the symptoms described.

Other Likely Diagnoses

  • Food Poisoning: Similar to gastroenteritis, food poisoning can cause abdominal pain, nausea, vomiting, and diarrhea, typically after consuming contaminated food or drinks.
  • Irritable Bowel Syndrome (IBS): Although IBS is more chronic, an acute exacerbation could present with these symptoms, especially if triggered by certain foods or stress.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis can cause abdominal pain, diarrhea, and sometimes vomiting, especially during a flare-up.

Do Not Miss Diagnoses

  • Appendicitis: Although the presence of diarrhea might be less common, appendicitis is a surgical emergency that can present with abdominal pain, nausea, and vomiting. It's crucial not to miss this diagnosis due to its severe consequences if untreated.
  • Intestinal Obstruction: This condition can cause severe abdominal pain, nausea, vomiting, and sometimes diarrhea. It requires immediate medical attention to prevent complications like bowel ischemia.
  • Mesenteric Ischemia: This is a life-threatening condition where blood flow to the intestines is compromised, leading to severe abdominal pain, nausea, and vomiting. Early diagnosis is critical for survival.

Rare Diagnoses

  • Intussusception: A condition where a part of the intestine slides into an adjacent part, which can cause abdominal pain, vomiting, and sometimes diarrhea. It's more common in children but can occur in adults.
  • Eosinophilic Gastroenteritis: A rare condition characterized by the infiltration of eosinophils into the gastrointestinal wall, leading to abdominal pain, nausea, vomiting, and diarrhea.
  • Whipple's Disease: A rare, systemic bacterial infection that can cause malabsorption, leading to diarrhea, abdominal pain, and weight loss, among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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