From the Research
Grapefruit seed extract should be avoided in patients taking blood thinners, such as warfarin, due to the potential risk of increased bleeding complications, as evidenced by a study published in the European Journal of Clinical Pharmacology in 2007 1. The interaction between grapefruit seed extract and blood thinners is a concern due to the potential inhibition of cytochrome P450 enzymes, particularly CYP3A4, which metabolizes many medications, including some blood thinners. This inhibition can lead to higher blood levels of the medication, enhancing its anticoagulant effects and increasing the risk of bleeding complications. Some key points to consider:
- Grapefruit seed extract may contain compounds that inhibit cytochrome P450 enzymes, leading to increased blood levels of medications, including blood thinners.
- The use of grapefruit seed extract in combination with blood thinners, such as warfarin, may increase the risk of bleeding complications, including easy bruising, nosebleeds, bleeding gums, or unusually heavy menstrual bleeding.
- Patients taking blood thinners should inform their healthcare provider about all supplements they are taking, including grapefruit seed extract, to minimize the risk of adverse interactions.
- Alternative supplements or therapies may be recommended for patients taking blood thinners, to minimize the risk of bleeding complications. It is essential to prioritize the patient's safety and well-being, and to take a cautious approach when considering the use of grapefruit seed extract in combination with blood thinners.