Do I need to test a patient's first-degree relatives for H. pylori infection after a diagnosis, especially if they have a history of gastric cancer or are from a high-risk population?

Testing First-Degree Relatives for H. pylori After Patient Diagnosis

Yes, you should test and treat first-degree relatives of your H. pylori-positive patient if there is a family history of gastric cancer, as these relatives have a 2-3 times increased risk of developing gastric cancer themselves, and H. pylori eradication is specifically recommended for cancer prevention in this high-risk group. 1

When Testing Relatives is Strongly Recommended

First-degree relatives with gastric cancer in the family:

• Testing and eradication should be considered for all first-degree relatives when any family member has been diagnosed with gastric cancer 1
• The risk increases dramatically (10-fold) when multiple first-degree relatives have gastric cancer 1
• This represents a Grade A recommendation with level 1a-4 evidence 1

Recurrent infection scenarios:

• If your index patient experiences recurrent H. pylori infection after initially successful eradication, suspect ongoing intrafamilial transmission 2
• Test all household members and treat those who are positive to break the transmission cycle 2
• Concurrent treatment of all positive household members prevents reinfection 2

When Routine Testing of Relatives is NOT Necessary

Standard H. pylori diagnosis without additional risk factors:

• If your patient has H. pylori-related peptic ulcer disease or dyspepsia but NO family history of gastric cancer, routine testing of asymptomatic relatives is not indicated 1
• The general 2-3 times increased transmission risk among first-degree relatives does not warrant universal screening in the absence of gastric cancer history 1, 2

Key Clinical Considerations

Risk stratification factors to assess:

• Family history of gastric cancer (most critical factor) 1
• Geographic origin from high gastric cancer incidence regions 1
• Age of relatives (gastric cancer risk increases significantly after age 45) 1
• Presence of alarm symptoms in relatives (weight loss, dysphagia, anemia) 1

Common pitfall to avoid:

• Do not confuse general familial clustering of H. pylori infection with the specific indication for testing relatives when gastric cancer is present in the family 1, 2
• The indication for testing is driven by gastric cancer prevention, not simply by the presence of H. pylori in the index patient 1

Additional High-Risk Scenarios for H. pylori Eradication

Beyond first-degree relatives of gastric cancer patients, consider testing and treating relatives who have: 1

• Previous gastric neoplasia (MALT lymphoma, adenoma, or cancer)
• Severe pan-gastritis or corpus-predominant gastritis
• Chronic gastric acid inhibition therapy planned for >1 year
• Strong environmental risk factors (heavy smoking, occupational dust exposure)