What is the treatment for a spreading rash on the face?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 11, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

For a spreading rash on the face, I recommend avoiding greasy creams, topical acne medications, and topical steroids, and instead using gentle, non-irritating treatments such as emollients and moisturizers to soothe the skin and reduce dryness and itching. When considering treatment options, it's essential to prioritize morbidity, mortality, and quality of life as the primary outcomes. According to the study by 1, treatments that should be avoided include greasy creams for basic care, manipulation of skin, hot blow-drying of the hair, wearing of tight shoes, topical acne medications, and topical steroids.

Some key considerations for treatment include:

  • Avoiding harsh soaps, fragrances, and makeup on the affected area
  • Washing with lukewarm water using a mild cleanser
  • Applying emollients and moisturizers to soothe the skin and reduce dryness and itching
  • Considering topical steroid preparations such as prednicarbate cream for inflammatory skin conditions like eczema and fissures
  • Using systemic treatment with oral H1-antihistamines such as cetirizine, loratadine, or fexofenadine for pruritus or itching

It's crucial to seek medical attention if the rash is accompanied by significant swelling, severe pain, fever, blisters, or affects your eyes or breathing. A healthcare provider can provide a proper diagnosis and prescribe stronger medications like prescription-strength corticosteroids, antihistamines, or antibiotics depending on the cause of the rash. Facial rashes can result from various conditions, including contact dermatitis, eczema, rosacea, or infections, and proper diagnosis is essential for effective treatment. Staying hydrated and avoiding known triggers can help prevent recurrence.

From the FDA Drug Label

Directions for itching of skin irritation, inflammation, and rashes: adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily For a spreading rash on the face, the treatment with hydrocortisone (TOP) is to apply to the affected area not more than 3 to 4 times daily for adults and children 2 years of age and older 2.

From the Research

Treatment Options for Spreading Rash on Face

  • The treatment for a spreading rash on the face depends on the underlying cause of the rash. According to 3, diagnosing a red rash on the face requires assessment of symptomology, age of onset, rash morphology, and 'clinical clues' that help delineate between differentials.
  • For atopic dermatitis, a common cause of facial rashes, treatment options include topical corticosteroids, pimecrolimus, and tacrolimus, as well as ultraviolet phototherapy for moderate to severe cases 4.
  • For herpes labialis, a viral infection that can cause a rash on the face, treatment options include topical antiviral drugs such as aciclovir, although the addition of hydrocortisone may not provide additional benefits and may pose risks 5.
  • In general, the approach to treating a generalized rash, including those on the face, involves a detailed history and physical examination to arrive at the most likely diagnosis, and treatment is tailored to the specific cause of the rash 6.
  • For herpes virus infections, which can cause rashes on the face, acyclovir and its analogues are the only approved medicines, and they work by inhibiting viral DNA replication 7.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Red in the face: Approach to diagnosis of red rashes on the face.

Australian journal of general practice, 2024

Research

Atopic Dermatitis: Diagnosis and Treatment.

American family physician, 2020

Research

Approach to Patient with a Generalized Rash.

Journal of family medicine and primary care, 2013

Research

Acyclovir in the Treatment of Herpes Viruses - A Review.

Current medicinal chemistry, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.