What is the appropriate workup and management for a pediatric patient presenting with acute onset upper respiratory infection (URI) symptoms?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: January 7, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Pediatric Acute URI Workup Template

History of Present Illness - Key Elements to Document

Focus your HPI on timing and pattern of symptoms to distinguish viral URI from bacterial complications.

Symptom Timeline (Critical for Diagnosis)

  • Day of illness onset and current day number—this is the single most important piece of information 1
  • Fever pattern: Document if fever occurred early (days 1-2) with constitutional symptoms versus late-onset or persistent fever 1
  • Nasal discharge progression: Clear → purulent → clear is typical viral pattern; document current quality and color 1
  • Cough characteristics: Daytime versus nighttime predominance, wet versus dry 1
  • Symptom trajectory: Improving, stable, or worsening after initial improvement ("double worsening") 1

Constitutional Symptoms

  • Fever height and duration (specifically note if ≥39°C/102.2°F) 1
  • Headache, myalgias, fatigue—typically resolve within 24-48 hours in viral URI 1
  • Appetite and oral intake status 2
  • Activity level compared to baseline 2

Red Flag Symptoms to Specifically Ask About

  • Duration >10 days without any improvement 1, 2
  • Concurrent high fever (≥39°C) AND purulent nasal discharge for ≥3 consecutive days 1
  • Worsening after initial improvement 1, 2
  • Respiratory distress signs (work of breathing, retractions) 2
  • Severe headache or facial pain 1

Past Medical History Essentials

  • History of recurrent sinusitis 2
  • Atopic conditions: eczema, asthma, allergic rhinitis 1
  • Daycare attendance (may have protracted symptoms up to 15 days) 2
  • Recent sick contacts 3
  • Immunization status 2

Physical Examination - Focused Findings

Vital Signs

  • Temperature: Specifically document if ≥39°C 1
  • Respiratory rate and work of breathing 2
  • Oxygen saturation if respiratory symptoms present 2

General Appearance

  • Ill-appearing versus well-appearing—critical distinction for severe onset bacterial sinusitis 1
  • Activity level and interaction 1

HEENT Examination

  • Nasal examination: Quality of discharge (clear, mucoid, purulent), turbinate erythema/swelling (nonspecific finding) 1
  • Sinus percussion: Not useful, do not perform 1
  • Allergic stigmata: Nasal crease, allergic shiners, pale nasal mucosa, cobblestoning of conjunctiva or pharynx 1
  • Pharynx: Erythema, exudate, tonsillar enlargement 4
  • Tympanic membranes: Assess for otitis media complication 5

Respiratory Examination

  • Auscultation for wheezing, crackles, or decreased breath sounds 4
  • Signs of increased work of breathing 2

Diagnostic Criteria for Bacterial Sinusitis

Make a presumptive diagnosis of acute bacterial sinusitis requiring antibiotics when ANY of the following are present: 1

  1. Persistent illness: Nasal discharge (any quality) OR daytime cough lasting >10 days without improvement
  2. Worsening course: New or worsening nasal discharge, cough, or fever after initial improvement
  3. Severe onset: Concurrent fever ≥39°C AND purulent nasal discharge for ≥3 consecutive days

Diagnostic Testing

Do NOT obtain imaging studies (plain films, CT, MRI, ultrasound) to distinguish bacterial sinusitis from viral URI 1

Management Algorithm

For Uncomplicated Viral URI (Most Cases)

Antibiotics provide no benefit and should NOT be prescribed for viral URI 2, 4, 6

Supportive care only:

  • Adequate hydration 2
  • Age-appropriate antipyretics (acetaminophen or ibuprofen) for fever/discomfort 2, 4
  • Saline nasal irrigation for symptom relief 2
  • Rest and comfortable humidity 2
  • Avoid decongestants and antihistamines in children <3 years due to adverse effects 2

Expected Course to Counsel Families

  • Total duration: 5-7 days typical 1, 2
  • Symptoms peak days 3-6 1, 3
  • Fever/constitutional symptoms resolve within 24-48 hours 1, 3
  • Nasal discharge may become purulent mid-illness then clear—this is normal 1
  • Some children have symptoms persisting after day 10 (especially daycare attendees) 2

When to Return for Re-evaluation

  • Symptoms persist >10 days without improvement 1, 2
  • Worsening after initial improvement 1, 2
  • High fever >3 days 2
  • Severe onset: fever ≥39°C with purulent discharge for 3-4 days 1
  • Signs of respiratory distress 2

Critical Pitfalls to Avoid

  • Do not prescribe antibiotics based on purulent nasal discharge alone—this commonly occurs in viral URI and does not indicate bacterial infection 1, 2
  • Do not use nasal discharge color to distinguish viral from bacterial infection 1, 2
  • Do not obtain imaging to make the diagnosis—clinical criteria are sufficient 1
  • Do not rely on physical examination findings (turbinate swelling, sinus percussion)—these are not helpful 1
  • Recognize that unnecessary antibiotics increase resistance, C. difficile risk, and provide no clinical benefit 2, 6

Contagiousness Counseling

  • Most contagious during first 3 days of illness 3
  • Can transmit before symptoms appear 3
  • Typically contagious for 7-10 days total 3
  • Purulent discharge does NOT indicate prolonged contagiousness—this is normal neutrophil response 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Viral Upper Respiratory Infection and Cough

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Contagious Period for Upper Respiratory Infections

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Viral upper respiratory tract infection and otitis media complication in young children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008

Related Questions

What treatment is recommended for worsening cough and congestion with yellow phlegm after a viral Upper Respiratory Infection (URI)?
What is the best course of treatment for a 13-year-old patient presenting with a 2-week history of runny nose and cough, recent fever and body aches, but stable vital signs and clear chest sounds?
What is the likely diagnosis and treatment for a 30-year-old male with a cough, sore throat, and chest tightness, with a negative chest X-ray (CXR) and suspected upper respiratory infection (URI)?
What is the treatment for a 2-day history of upper respiratory infection (URI) and sinus pressure?
Is there concern for a 5-month-old infant with a recent history of fever, now presenting with hoarseness, who has received multiple doses of Tylenol (acetaminophen) and is currently afebrile with normal feeding and elimination patterns?
What is the recommended combination therapy for a patient with treatment-resistant bipolar disorder, considering lamictal (lamotrigine) plus either valproate or lithium?
What is the maximum safe sodium correction in 24 hours for a patient with hyponatremia, particularly in those with chronic hyponatremia or underlying conditions?
What are the guidelines for using atropine in adults and children with various medical conditions?
What is the best treatment approach for a middle-aged or older patient with calcaneal enthesophytes, a history of plantar fasciitis or Achilles tendinitis, and potential impaired renal function?
What are the most common conditions and presentations seen during an outpatient pediatrics rotation or clerkship?
What is the recommended treatment for an adult patient with otitis media (middle ear infection)?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.