What is the dosing for Solifenacin?

From the Guidelines

The dosing for Solifenacin is typically 5 mg.

Dosing Details

• The evidence from the studies 1 suggests that Solifenacin is effective in treating overactive bladder at a dose of 5 mg.
• A study by Drake et al. (2016) mentioned in 1 evaluated the efficacy, safety, and tolerability of combination therapy (solifenacin 5 mg plus mirabegron 50 mg) versus monotherapy (solifenacin 5 or 10 mg).
• The American College of Physicians guideline 1 also mentions that Solifenacin achieved continence more than placebo at a dose of 5 mg, with a number needed to benefit (NNTB) of 9 [CI, 6 to 17].
• Additionally, the evidence suggests that higher doses of Solifenacin (10 mg/d) do not decrease the frequency of UI episodes and are associated with increased risk for adverse effects 1.

Key Points

• Solifenacin 5 mg is the typical dose for treating overactive bladder.
• Higher doses (10 mg/d) may not provide additional benefits and may increase the risk of adverse effects.
• Combination therapy with mirabegron 50 mg may be considered, but the evidence is based on a specific study 1 and may not be generalizable to all patients.

From the FDA Drug Label

1. 1 Dosing Information The recommended oral dose of solifenacin succinate is 5 mg once daily. If the 5 mg dose is well tolerated, the dose may be increased to 10 mg once daily.
2. 2 Dosing Recommendations in Patients with Renal Impairment Do not exceed 5 mg once daily in patients with severe renal impairment (CLcr < 30 mL/min/1.73 m2)
3. 3 Dosing Recommendations in Patients with Hepatic Impairment Do not exceed 5 mg once daily in patients with moderate hepatic impairment (Child-Pugh B).
4. 4 Dosing Recommendations in Patients Taking CYP3A4 Inhibitors Do not exceed 5 mg once daily when solifenacin succinate is administered with strong CYP3A4 inhibitors such as ketoconazole

The dosing for Solifenacin is:

• Recommended dose: 5 mg once daily, which may be increased to 10 mg once daily if well tolerated.
• Renal impairment: Do not exceed 5 mg once daily in patients with severe renal impairment.
• Hepatic impairment: Do not exceed 5 mg once daily in patients with moderate hepatic impairment.
• CYP3A4 inhibitors: Do not exceed 5 mg once daily when administered with strong CYP3A4 inhibitors 2.

From the Research

Dosing for Solifenacin

• The recommended dose of solifenacin is 5 mg once daily, which can be increased to 10 mg once daily if the 5 mg dose is well tolerated 3.
• Solifenacin is available in two doses: 5 mg and 10 mg, taken once daily 4, 5.
• Flexible dosing with solifenacin provides 24-hour control of overactive bladder (OAB) symptoms 4.
• The efficacy of solifenacin (5 or 10 mg/day) is at least equal to that of extended-release (ER) tolterodine (4 mg/day) in reducing the mean number of micturitions per 24 hours and urgency episodes, and in increasing the volume voided per micturition 6.
• Doses exceeding 5 mg/day are not recommended for patients with moderate hepatic impairment, patients with severe renal impairment, and subjects undergoing concomitant therapy with CYP3A4 inhibitors 6.