What are the causes of periorbital edema (swelling around the eyes)?

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Last updated: April 11, 2025 • View editorial policy

Differential Diagnosis for Eye Bags Under Eyes

  • Single Most Likely Diagnosis + Allergic rhinitis: This is a common condition that can cause puffiness and swelling under the eyes due to increased blood flow and fluid accumulation.
  • Other Likely Diagnoses + Fatigue and sleep deprivation: Lack of sleep can lead to fluid retention, causing puffiness under the eyes. + Dehydration: Inadequate fluid intake can cause the body to retain water, leading to swelling under the eyes. + Aging: As we age, the skin under the eyes becomes thinner, and fat can bulge out, creating the appearance of eye bags. + Sinusitis: Inflammation of the sinuses can cause swelling and puffiness under the eyes.
  • Do Not Miss Diagnoses + Thyroid eye disease: This condition, often associated with Graves' disease, can cause bulging of the eyes and swelling of the tissues around the eyes. + Orbital cellulitis: A bacterial infection of the tissues surrounding the eye, which can cause severe swelling, redness, and pain. + Angioedema: A condition characterized by rapid swelling of the skin and mucous membranes, which can be life-threatening if not treated promptly.
  • Rare Diagnoses + Sjögren's syndrome: An autoimmune disorder that can cause inflammation and swelling in various parts of the body, including under the eyes. + Amyloidosis: A condition in which abnormal proteins accumulate in the body, potentially causing swelling and puffiness under the eyes. + Lymphedema: A condition characterized by the accumulation of lymph fluid, which can cause swelling in various parts of the body, including under the eyes.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.