Lyrica and Taste Changes
Lyrica (pregabalin) does not cause changes in taste as a recognized adverse effect. The available evidence, including comprehensive pharmacological reviews and clinical studies, does not identify taste disturbances among pregabalin's documented side effects.
Evidence from Pharmacological Studies
Pregabalin's mechanism of action involves binding to the α2δ subunit of voltage-gated calcium channels, which reduces excitatory neurotransmitter release but has no demonstrated effects on sensory pathways related to taste perception 1, 2.
The well-established adverse effect profile of pregabalin includes dizziness, somnolence, weight gain, and constipation, but taste alterations are notably absent from this profile 3.
In a study specifically examining severe adverse effects of pregabalin, constipation was identified as the most frequent adverse effect requiring drug withdrawal (6.3% of patients), while taste changes were not reported 4.
Clinical Context and Alternative Causes
If a patient taking Lyrica reports taste changes, investigate other potential causes first, as this is not a characteristic side effect of pregabalin 5.
Other medications commonly cause taste disturbances and should be considered:
Viral infections, particularly COVID-19, cause taste/smell loss in 59-86% of cases and represent a more likely explanation for new-onset taste disturbances 5.
Common Pitfalls to Avoid
Do not discontinue pregabalin based solely on taste complaints without investigating more probable causes, as the therapeutic benefits of pregabalin for its approved indications (neuropathic pain, seizures, anxiety) are well-established 3.
Review the patient's complete medication list, as polypharmacy increases the likelihood that another agent is responsible for taste alterations 5.
Consider underlying medical conditions affecting taste perception, including nutritional deficiencies, oral health issues, and systemic diseases 5.