Can Nexplanon (etonogestrel) cause mastalgia (breast pain)?

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Last updated: April 11, 2025View editorial policy

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From the Guidelines

Nexplanon can cause breast pain as a potential side effect in some users. This contraceptive implant contains etonogestrel, a synthetic progestin hormone, which can lead to breast tenderness or pain. Although the provided study 1 does not specifically mention breast pain as a side effect of Nexplanon, it is known that hormonal contraceptives, including progestin implants, can cause changes in breast tissue leading to discomfort or pain.

Key Points to Consider

  • Breast pain is a possible side effect of hormonal contraceptives, including Nexplanon
  • The mechanism behind this side effect relates to how the progestin affects breast tissue, causing fluid retention and sensitivity
  • If you experience severe or persistent breast pain while using Nexplanon, you should consult your healthcare provider to evaluate the cause of the pain
  • For mild discomfort, over-the-counter pain relievers like ibuprofen may help manage symptoms It's essential to weigh the benefits of using Nexplanon for contraception against potential side effects like breast pain, considering the overall impact on quality of life and health outcomes. Given the information available, it is crucial to discuss any concerns or side effects with a healthcare provider to make an informed decision about using Nexplanon or any other contraceptive method, as noted in guidelines and studies such as 1.

From the Research

Breast Pain and Nexplanon

  • There is no direct evidence in the provided studies that Nexplanon causes breast pain 2, 3, 4, 5.
  • The studies focus on the management and treatment of mastalgia, which is breast pain, but do not mention Nexplanon as a cause of breast pain.
  • One study discusses Nexplanon as a long-term reversible contraception method, but it does not mention breast pain as a side effect 6.
  • The common causes of breast pain mentioned in the studies include cyclical mastalgia, hormonal changes, and noncyclical breast pain, which can be idiopathic or related to various factors such as chronic pain syndromes, infections, and musculoskeletal abnormalities 2, 3, 4, 5.
  • Treatment options for breast pain include reassurance, breast support, topical NSAID gel, and antiestrogen therapy, but Nexplanon is not mentioned as a treatment or cause of breast pain 2, 3, 4, 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Evidence for the management of mastalgia.

Current medical research and opinion, 2004

Research

Clinical management of idiopathic mastalgia: a systematic review.

Journal of primary health care, 2018

Research

Nexplanon: the new implant for long-term contraception. A comprehensive descriptive review.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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