From the Research
The IGF-1 level of -8, DHEA of 394, and DHEAS of 100 in a 52-year-old female with a pituitary adenoma are not normal values and require further evaluation by an endocrinologist. The IGF-1 value is particularly concerning as it should be a positive number, typically ranging from 50-300 ng/mL depending on the lab reference range. A negative value likely represents a reporting error or unusual lab notation. The DHEA level of 394 appears elevated (normal range typically 35-350 ng/dL for this age), while the DHEAS of 100 is within normal limits for a postmenopausal woman (normal range approximately 30-260 μg/dL) 1.
These hormone abnormalities should be evaluated in the context of the patient's pituitary adenoma, which may be affecting normal hormone production. The patient should consult with an endocrinologist for proper interpretation of these results, repeat testing if necessary, and development of a treatment plan that may include medication to normalize hormone levels or management of the pituitary adenoma through medication or possibly surgery, depending on the adenoma's size and hormone-producing status. According to a recent study, DHEA supplementation may increase serum IGF-I levels, especially in women and older subjects 1.
Key considerations in the management of this patient include:
- Evaluation of the pituitary adenoma and its potential impact on hormone production
- Interpretation of the IGF-1, DHEA, and DHEAS levels in the context of the patient's age and medical history
- Development of a treatment plan that may include medication, surgery, or other interventions to normalize hormone levels and manage the pituitary adenoma
- Regular follow-up with an endocrinologist to monitor the patient's condition and adjust the treatment plan as needed.