What are the auscultatory findings for mitral stenosis and an S4 heart sound in patients, particularly women and older adults, with a history of rheumatic fever and cardiovascular disease?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: January 8, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Auscultatory Findings in Mitral Stenosis

In mitral stenosis, the classic auscultatory findings include a loud S1, an opening snap after S2, and a low-pitched mid-diastolic rumbling murmur with presystolic accentuation (in sinus rhythm), best heard at the apex with the bell of the stethoscope. 1

Classic Mitral Stenosis Findings

The characteristic auscultatory sequence in rheumatic mitral stenosis includes:

  • Loud first heart sound (S1): The increased closing force of the stenotic mitral valve produces an accentuated S1, creating a "tapping" apex beat on palpation 1, 2

  • Opening snap: This high-pitched sound occurs after S2 as the stenotic mitral valve leaflets abruptly halt their opening motion due to commissural fusion and diastolic doming 1

  • Mid-diastolic murmur: A low-pitched rumbling murmur follows the opening snap, best appreciated at the apex in the left lateral decubitus position 1, 2

  • Presystolic accentuation: In patients maintaining sinus rhythm, the murmur intensifies just before S1 due to increased flow velocity from atrial contraction 2

Additional Cardiac Findings

Accentuated pulmonary component of S2 (P2) is commonly present, reflecting elevated pulmonary artery pressures that develop as mitral stenosis progresses to severe stages 1, 2

  • A palpable P2 and left parasternal heave indicate significant pulmonary hypertension secondary to chronic left atrial pressure elevation 2

S4 Heart Sound Considerations

An S4 heart sound is NOT a typical finding in mitral stenosis and should prompt consideration of alternative or coexisting pathology. 1

The S4 (atrial gallop) represents forceful atrial contraction against a stiff, non-compliant ventricle. In mitral stenosis:

  • The stenotic mitral valve itself creates resistance to left ventricular filling, but the left ventricle typically remains normal in isolated mitral stenosis 1

  • An S4 would suggest concurrent left ventricular pathology such as hypertension, coronary artery disease, or hypertrophic cardiomyopathy 1

  • In older adults with rheumatic mitral stenosis, an S4 may reflect coexisting diastolic dysfunction from age-related changes, hypertension, or atherosclerotic disease rather than the mitral stenosis itself 1

Clinical Context and Pitfalls

The presence of only an isolated systolic murmur in patients with rheumatic fever history frequently represents mitral regurgitation, often due to mitral valve prolapse rather than stenosis. 3

Important diagnostic considerations:

  • Rheumatic mitral valve disease affects the mitral valve in 99-100% of cases, with mitral regurgitation being the most frequent finding (87-94% of cases) 4, 5

  • Pure mitral stenosis without any regurgitation is less common than combined lesions 4

  • The intensity of auscultatory findings varies with heart rate—tachycardia shortens diastole and may make the murmur less apparent 1

  • In atrial fibrillation, the presystolic accentuation disappears, and the diastolic murmur becomes more uniform 1

Clinical auscultation skills remain essential, as physical examination findings of an opening snap and characteristic murmur establish the diagnosis of clinical carditis in acute rheumatic fever. 1, 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Mitral stenosis in a girl of five years.

Mymensingh medical journal : MMJ, 2006

Guideline

Echocardiographic Diagnosis of Rheumatic Mitral Valve Disease

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Acute Rheumatic Fever Diagnosis and Cardiac Manifestations

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Related Questions

Can scarlet fever cause mitral stenosis in adulthood?
What cardiac complication is most closely associated with rheumatic fever?
What is the most likely cause of a pansystolic murmur radiating to the axilla in an asymptomatic patient?
What is the significance and treatment of a Carey Coombs murmur in a patient?
What is the most likely cause of a pansystolic murmur radiating to the axilla in an asymptomatic young man?
What are the safe alternatives to Clenbuterol for weight loss or athletic performance enhancement in a general population?
What is the recommended IV antibiotic (abx) regimen for a patient with an infectious abdominal perforation, considering their past medical history and potential antibiotic allergies or resistance?
What is the optimal blood pressure control strategy for a postoperative patient with a history of hypertension?
What is more effective for a patient with a history of zopiclone (a non-benzodiazepine hypnotic agent) dependence, doxepin 6mg or trazodone (an antidepressant) 100mg, for treating insomnia?
Can a hyperdynamic left ventricle (LV) in a patient with sepsis cause elevated N-terminal pro b-type natriuretic peptide (NT-proBNP) levels?
How to manage a patient with antisynthetase syndrome and positive anti-Jo1, who is on rituximab (Rituxan) every 6 months, prednisone (Deltasone) 10mg, mycophenolate mofetil (Cellcept) 1000mg BID, and nintedanib (Ofev) 150mg BID, presenting with worsening dyspnea, productive whitish sputum, high-grade fever, and hypoxia with oxygen saturation at 88% on room air, and positive rhinovirus/enterovirus, elevated C-reactive protein (CRP) 23, procalcitonin 32, lactic acid 27, and leukocytosis 16000, with normal creatine kinase (CK) level, and pending sputum culture?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.