Aristada 882mg Administration Frequency
Aristada (aripiprazole lauroxil) 882mg is administered either monthly (every 4 weeks) or every 6 weeks, depending on the selected dosing regimen. 1, 2
Available Dosing Options for Aristada 882mg
Aristada 882mg offers two distinct administration schedules:
- Monthly dosing (every 4 weeks): This is one of the standard regimens where 882mg is administered once every 4 weeks 2
- Every 6 weeks dosing: Aristada 882mg can also be administered every 6 weeks as an alternative extended dosing interval 1, 2
Initiation Requirements
When starting Aristada 882mg, you must address the delay in achieving therapeutic aripiprazole concentrations:
- Standard 21-day initiation regimen: Oral aripiprazole supplementation is required for the first 21 days after the initial Aristada injection 1
- Alternative 1-day initiation regimen: A nano-crystalline formulation (ALNCD) plus a single 30mg oral aripiprazole dose can achieve therapeutic concentrations within 4 days, eliminating the need for 21 days of oral supplementation 3
The 1-day initiation regimen is suitable for starting treatment with the 882mg dose (whether monthly or every 6 weeks), and allows a window of up to 10 days between initiation and the first Aristada injection 3
Pharmacokinetic Considerations
The extended dosing intervals are supported by the pharmacokinetic profile of aripiprazole lauroxil:
- Maximum aripiprazole concentrations are achieved 24-35 days after injection 2
- The mean elimination half-life is approximately 55 days for the 882mg dose 2
- Steady-state concentrations are maintained throughout the dosing interval, whether administered every 4 weeks or every 6 weeks 2
- The 882mg every 6 weeks regimen provides mean steady-state concentrations of 131.1 ng/ml, which falls within the therapeutic range 2
Clinical Monitoring
Regardless of whether you select monthly or every-6-week dosing, therapeutic efficacy should be assessed after at least 4-6 weeks at the established dose before determining treatment adequacy 4