Why is it recommended to associate sacubitril (angiotensin receptor-neprilysin inhibitor) with valsartan (angiotensin II receptor blocker) rather than giving valsartan alone in patients with heart failure, particularly those with reduced ejection fraction?

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Last updated: January 8, 2026 • View editorial policy

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Related Questions

What is the recommended use of Angiotensin-Receptor Neprilysin Inhibitors (ARNI) such as sacubitril/valsartan (Sacubitril/Valsartan) in a hospital setting for patients with heart failure with reduced ejection fraction?

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What medication class can be added to a patient with heart failure (HF) to reduce mortality, morbidity, and risk of HF readmission, given a recent HF exacerbation?

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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