What is the smallest recommended needle size for Platelet-rich Plasma (PRP)?

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DS

Dainyal Siddiqui, MD

Internal Medicine

MJ

Manuel Jimenez, MD

Cardiology

FP

Franz Pierre-Louis, MD

Infectious Disease

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Last updated: February 14, 2025 • View editorial policy

From the Research

  • The smallest recommended needle size for PRP injections is 30 G, as suggested by a study published in 2014 1.
  • This study found that the use of local anesthetics with PRP injections could compromise the therapeutic potential of PRP, and recommended using 30 G needles to minimize injection pain.
  • Another study published in 2021 found that changing the needle diameter does not affect the width or depth of the PRP spread in the dermis 2.
  • However, this study did not specifically recommend a needle size for PRP injections.
  • The other studies reviewed did not provide information on the recommended needle size for PRP injections 3, 4, 5.

References

5
Research

Evidence-based indications of platelet-rich plasma therapy.

Expert review of hematology, 2021

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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