From the Research
Jublia (efinaconazole) can be used for longer than 48 weeks if needed, as evidenced by a study published in 2024, which showed that extended use of efinaconazole 10% topical solution for up to 24 months remains safe and can provide continuing benefits for dermatophyte toenail onychomycosis 1. The standard treatment course is typically 48 weeks for onychomycosis (fungal nail infection). If your nail infection hasn't completely resolved after the initial treatment period, your healthcare provider may recommend continuing treatment. Jublia is applied once daily to affected toenails using the built-in brush applicator, and it's essential to apply it to the entire nail surface and under the nail edge. The medication works by inhibiting fungal growth and allowing a healthy nail to grow out, which takes time since nails grow slowly. Complete nail clearing may not occur even after 48 weeks of treatment, and some patients may require longer therapy for optimal results. Always consult with your healthcare provider before extending treatment beyond the recommended duration, as they can evaluate your specific situation and determine if continued use is appropriate. Some key points to consider when using Jublia for an extended period include:
- The medication has been shown to be safe and effective in patients of all ages, including pediatrics 2
- Efinaconazole 10% solution has comparable efficacy to systemic antifungal agents such as itraconazole, and a favorable adverse events profile with minimal systemic exposure and no drug-drug interactions 2
- Clinically meaningful results (a 40% improvement in the involvement of the diseased nail) were achieved with efinaconazole within six months in half the patients treated, and in over 90% of patients by study end 3
- A study published in 2022 found that efinaconazole 10% topical solution is a safe and effective treatment for adult and pediatric onychomycosis, with a satisfactory mycological and clinical cure 4