What are the guidelines for using Transmet (generic name unknown) 500 mg in an adult patient?

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Transmet 500 mg: Identification and Clinical Use

I cannot provide specific dosing or usage guidelines for "Transmet 500 mg" because this medication name does not appear in any of the provided clinical guidelines, drug labels, or research evidence, and it is not a recognized medication in standard medical references.

Critical Clarification Needed

The term "Transmet" requires clarification before any clinical recommendations can be made. This could potentially refer to:

  • Trimetrexate (TMTX): An antifolate chemotherapy agent used in relapsed T-cell lymphoma and gastrointestinal carcinomas, typically dosed at 200 mg/m² IV every 14 days for lymphoma 1 or 20-110 mg/m² in combination regimens for colorectal cancer 2

  • A misidentification of another medication: The name may be a local brand name, abbreviation, or transcription error for a different drug

  • TransMet trial reference: This refers to a liver transplantation protocol for colorectal liver metastases 3, not a medication

Important Safety Considerations

Without proper medication identification, prescribing or taking any medication labeled "Transmet 500 mg" poses significant patient safety risks, including:

  • Potential for medication errors and adverse drug events
  • Inability to assess drug interactions or contraindications
  • Lack of appropriate monitoring parameters
  • Unknown side effect profile

Recommended Action

Verify the exact generic and brand name of the medication with the prescribing physician, pharmacist, or medication label before administration. If this is trimetrexate, note that it requires specialized oncology expertise and is dosed based on body surface area (mg/m²), not as a fixed 500 mg dose 1, 2.

References

Research

Trimetrexate in relapsed T-cell lymphoma with skin involvement.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002

Research

Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994

Research

Optimizing liver transplant outcomes for colorectal liver metastases in the united states.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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