What is the diagnosis for a patient with a 9mm noncalcified middle lobe nodule and a mildly distended, fluid-filled appendix, concerning for early acute uncomplicated appendicitis and a probable infectious/inflammatory pulmonary nodule?

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Last updated: April 11, 2025View editorial policy

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Differential Diagnosis

  • Single most likely diagnosis
    • Acute appendicitis: The findings of a mildly distended, fluid-filled appendix without surrounding inflammatory fat stranding are consistent with early or developing acute uncomplicated appendicitis.
    • Probable infectious/inflammatory middle lobe nodule: The presence of a 9 mm noncalcified middle lobe nodule with subtle surrounding ground-glass opacity suggests an infectious or inflammatory etiology.
  • Other Likely diagnoses
    • Viral pneumonia: The middle lobe nodule with ground-glass opacity could also be consistent with viral pneumonia, especially in the absence of other symptoms.
    • Bacterial pneumonia: Although less likely, bacterial pneumonia could also present with a similar radiographic appearance.
    • Appendiceal muccele: The fluid-filled appendix could be a muccele, although this would be less likely without other symptoms or signs of appendiceal obstruction.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Appendiceal rupture: Although the current findings do not suggest rupture, it is essential to consider this possibility, as delayed diagnosis can lead to severe consequences.
    • Pulmonary embolism: The presence of a middle lobe nodule could be a pulmonary infarct, and it is crucial to consider pulmonary embolism, especially if the patient has risk factors.
    • Malignancy: Although less likely, it is essential to consider the possibility of malignancy, especially if the nodule does not resolve with treatment.
  • Rare diagnoses
    • Hydatid cyst: The fluid-filled appendix could be a hydatid cyst, although this would be rare in this context.
    • Echinococcal disease: The middle lobe nodule could be an echinococcal cyst, although this would be rare and typically associated with other symptoms.

SOAP Note

S - The patient presents with a mildly distended, fluid-filled appendix and a 9 mm noncalcified middle lobe nodule with subtle surrounding ground-glass opacity. O - The radiographic findings are consistent with early or developing acute uncomplicated appendicitis and a probable infectious/inflammatory middle lobe nodule. A - The differential diagnosis includes acute appendicitis, probable infectious/inflammatory middle lobe nodule, viral pneumonia, bacterial pneumonia, appendiceal muccele, appendiceal rupture, pulmonary embolism, malignancy, hydatid cyst, and echinococcal disease. P - The patient should undergo further evaluation, including laboratory tests and potentially a follow-up imaging study, to confirm the diagnosis and guide treatment. Antibiotics and appendectomy may be necessary, depending on the final diagnosis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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