From the Research
I strongly advise against combining Edronax (reboxetine) 4mg with sertraline 100mg without proper medical supervision, as this combination may increase the risk of side effects and requires careful consideration by your healthcare provider. This combination involves two different antidepressants that work through different mechanisms, with sertraline being an SSRI that increases serotonin levels and Edronax being a norepinephrine reuptake inhibitor that increases norepinephrine. While this combination might help with tension and constant brain activity in some cases of generalized anxiety disorder (GAD), it also increases the risk of side effects including elevated blood pressure, increased heart rate, excessive sweating, and potentially serotonin syndrome 1.
Your description of constant brain activity but not much worry suggests your symptoms might not align perfectly with typical GAD. According to a study published in 2018, SSRIs and SNRIs represent the first-line psychopharmacologic treatment for adults with GAD, while second-line pharmacotherapies include buspirone, benzodiazepines, and pregabalin 1. Another study published in 2018 found that benzodiazepines are the most effective drug for treating GAD, but they also have a higher risk of side effects and dependence 2.
Given the potential risks and benefits of this combination, I strongly recommend discussing your specific symptoms and concerns with your doctor before starting this combination, as they can evaluate whether this approach is appropriate for your particular situation and monitor for any adverse effects. Your doctor can help you weigh the potential benefits of this combination against the potential risks and determine the best course of treatment for your specific needs. Additionally, cognitive-behavioral therapy (CBT) has been shown to be an effective treatment for GAD, and may be a useful adjunct to pharmacotherapy 3.
Some key points to consider when discussing this combination with your doctor include:
- The potential benefits of combining Edronax and sertraline for treating GAD, including improved symptoms and quality of life
- The potential risks of this combination, including increased side effects and serotonin syndrome
- Alternative treatment options, such as CBT or other pharmacotherapies, that may be more effective or have a better safety profile for your specific needs.