From the Research
Rectal Bioavailability of Diphenoxylate
- There are no direct studies on the rectal bioavailability of Diphenoxylate provided in the given evidence 1, 2, 3, 4, 5.
- However, studies on other drugs suggest that rectal administration can result in varying bioavailability depending on the drug and formulation 1, 2, 4.
- The rectal route of administration may offer advantages such as partial avoidance of hepatic first-pass elimination for high clearance drugs 1.
- The bioavailability of rectally administered drugs can be influenced by factors such as the nature of the suppository base, use of surfactants or other additives, and particle size of the active ingredient 1.
- Studies on other drugs, such as methadone, have shown that rectal administration can result in rapid absorption and high bioavailability 4.
- Diphenoxylate is used to treat chronic diarrhea and fecal incontinence, and its effects on stool frequency and weight have been studied 5, but its rectal bioavailability remains unknown based on the provided evidence.