From the Research
High iron levels, known as iron overload or hemochromatosis, can potentially contribute to depression and anxiety symptoms. Excess iron can accumulate in various organs including the brain, where it may disrupt neurotransmitter function and cause oxidative stress that damages brain cells, as discussed in the context of iron metabolism and its impact on human health 1. This neurological impact can affect mood regulation systems, potentially leading to symptoms of depression or anxiety. People with hereditary hemochromatosis or those who receive frequent blood transfusions are at higher risk for iron overload. The diagnosis and management of hereditary haemochromatosis are crucial, as simple interventions like phlebotomy can prevent or reverse organ damage from iron overload 2.
If you suspect high iron levels might be affecting your mental health, ask your doctor for a serum ferritin test and transferrin saturation measurement to check your iron status. Treatment typically involves therapeutic phlebotomy (blood removal) to reduce iron levels, and in some cases chelation therapy with medications like deferoxamine or deferasirox, which have been shown to be effective in reducing iron burden in patients with hereditary hemochromatosis 3. Addressing iron overload often leads to improvement in associated symptoms, including potential mood disturbances. However, depression and anxiety have multiple potential causes, so a comprehensive evaluation by healthcare providers is important for proper diagnosis and treatment. For patients refractory to or intolerant of phlebotomy, alternative treatment options such as chelating agents and erythrocytapheresis can be considered 4.