From the Guidelines
For a blood sugar level (BSL) of 15 mmol/L, I recommend increasing the Ryzodeg dose by 1–2 units or 10–15% twice weekly, as per the guidelines outlined in the 2023 standards of care in diabetes 1. When adjusting the dose, it's essential to consider the individual's insulin sensitivity, meal intake, and activity level. Ryzodeg is a combination insulin containing 70% insulin degludec (long-acting) and 30% insulin aspart (rapid-acting), which provides both basal and prandial coverage. Some key points to consider when titrating Ryzodeg dose include:
- Increase dose by 1–2 units or 10–15% twice weekly, as recommended in the 2023 standards of care in diabetes 1
- For hypoglycemia, determine the cause and lower the corresponding dose by 10–20% if no clear reason is found, as suggested in the same guidelines 1
- Monitor blood sugar levels regularly to assess the effectiveness of the adjusted dose and make further adjustments as needed. It's crucial to consult with a healthcare provider before making significant changes to the insulin regimen, as they can provide personalized dosing recommendations based on individual needs and medical history.
From the Research
Ryzodeg Dosing for BSL 15
- The ideal dosing for Ryzodeg (insulin degludec/insulin aspart) when the blood sugar level (BSL) is 15 mmol/L is not explicitly stated in the provided studies 2, 3, 4, 5, 6.
- However, the studies suggest that Ryzodeg can be effective in lowering fasting plasma glucose levels and reducing the risk of hypoglycaemia in patients with type 2 diabetes 5, 6.
- The dosing of Ryzodeg is typically individualized and based on the patient's specific needs and response to the medication 4.
- In general, the starting dose of Ryzodeg is typically in the range of 10-20 units per day, with adjustments made based on the patient's glucose levels and other factors 3.
- It is recommended that healthcare professionals consult the product labeling and clinical guidelines for specific dosing recommendations for Ryzodeg 2, 3, 4, 5, 6.
Key Considerations
- The patient's baseline characteristics, such as HbA1c level, duration of diabetes, and body mass index (BMI), may influence the dosing and efficacy of Ryzodeg 6.
- Ryzodeg has been shown to be effective in patients with type 2 diabetes, regardless of their baseline characteristics 6.
- The medication should be titrated to achieve optimal glucose control, with careful monitoring of glucose levels and adjustment of the dose as needed 3, 4, 5.