From the Research
Neuropraxia is a temporary nerve injury that typically resolves spontaneously within weeks to months without specific treatment, and management primarily involves protecting the affected area and maintaining joint mobility through gentle range-of-motion exercises. Neuropraxia is characterized by a disruption in nerve conduction without damage to the nerve structure itself, causing symptoms like numbness, tingling, weakness, or paralysis in the affected area. The condition typically results from compression, stretching, or mild trauma to a nerve.
Some studies have investigated the use of gabapentinoids, such as pregabalin and gabapentin, in the management of neuropathic pain, which may be associated with neuropraxia 1, 2. However, these studies are more relevant to the treatment of neuropathic pain rather than neuropraxia specifically. For example, a study published in 2022 compared the therapeutic effects of pregabalin and gabapentin after transforaminal epidural nerve block in lumbar radiculopathy, finding that both medications can be equally used to reduce pain in these patients 3. Another study published in 2025 compared the effects of pregabalin, gabapentin, and duloxetine in diabetic peripheral neuropathy, finding that duloxetine and pregabalin effectively treat this condition, while gabapentin and pregabalin are suitable for patients with higher HbA1c levels 4.
In terms of specific management, physical therapy may be recommended to prevent muscle atrophy and maintain function during recovery. Pain management can include acetaminophen or NSAIDs like ibuprofen (400-600mg every 6-8 hours) for mild discomfort. In some cases, a splint or brace may be used to protect the affected limb. Neuropraxia differs from more severe nerve injuries like axonotmesis or neurotmesis because the nerve axon remains intact, allowing for complete recovery once the local physiological block resolves. If symptoms persist beyond 3-6 months or worsen over time, further evaluation with nerve conduction studies or electromyography may be necessary to rule out more serious nerve damage requiring surgical intervention.
Key points to consider in the management of neuropraxia include:
- Protecting the affected area and avoiding further injury
- Maintaining joint mobility through gentle range-of-motion exercises
- Using physical therapy to prevent muscle atrophy and maintain function
- Managing pain with acetaminophen or NSAIDs as needed
- Considering the use of a splint or brace to protect the affected limb
- Monitoring for signs of more severe nerve damage and seeking further evaluation if symptoms persist or worsen.