From the FDA Drug Label
Nuvazil™II is a Silicone Gel Scar Dressing which is soft, comfortable, self-adhesive and Reusable. Nuvazil™II flattens, softens and fades both existing and new hypertrophic scars or keloids. Indications and Usage For non-invasive management of both existing and new hypertrophic scars or keloids.
Silicone improves scars by:
- Flattening hypertrophic scars or keloids
- Softening hypertrophic scars or keloids
- Fading hypertrophic scars or keloids This is based on the information provided in the drug labels 1 and 1.
From the Research
Silicone improves scars by creating a protective barrier that increases hydration, regulates collagen production, and reduces inflammation, as supported by the most recent and highest quality study available 2. When applied to healing wounds or existing scars, silicone sheets or gels work by creating an occlusive environment that prevents water loss from the skin surface. This increased hydration helps normalize the production of collagen, preventing the excessive buildup that leads to raised, hypertrophic, or keloid scars. Some key points to consider when using silicone for scar improvement include:
- Applying silicone products to clean, dry skin and using them consistently for at least 12 hours daily over 2-3 months
- Starting treatment early in the healing process for best results, although silicone can also improve older scars
- Using silicone therapy alongside other scar treatments like massage or pressure therapy, as it is non-invasive and generally safe with minimal side effects
- Considering common silicone-based products like Scaraway, Mederma, and Kelo-cote, which come as sheets, gels, or strips The treatment works through several mechanisms, including:
- Maintaining skin moisture
- Protecting the scar from bacterial invasion
- Modulating growth factors involved in scarring
- Reducing tension on the wound It's essential to note that while silicone therapy is beneficial, the current evidence is limited, and further well-designed studies are required to reduce uncertainty around decision-making in the use of silicone gel sheeting to treat keloid scars 2.