What is the hourly release rate of 20 mg transdermal patches?

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Liberación Horaria de Parches Transdérmicos de 20 mg

Los parches transdérmicos de buprenorfina de 20 μg/h liberan 20 microgramos de fármaco por hora de manera continua durante 7 días. 1

Aclaración Importante sobre Nomenclatura

La designación "20 mg" en parches transdérmicos es incorrecta o confusa. Los parches transdérmicos se dosifican por su tasa de liberación por hora, no por contenido total:

  • Parches de buprenorfina: Se denominan por su liberación horaria (5,10,20 μg/h = microgramos por hora), no por contenido total 1
  • Parches de estradiol: Se denominan por liberación en 24 horas (50,100 mcg/24h), no por contenido total 2, 3
  • Parches de testosterona: Se denominan por liberación en 24 horas (2 mg/24h, 4 mg/24h) 4

Tasas de Liberación Según Tipo de Parche

Parches de Buprenorfina (Analgésico Opioide)

  • Parche de 5 μg/h: Libera 5 microgramos por hora durante 7 días 1
  • Parche de 10 μg/h: Libera 10 microgramos por hora durante 7 días 1
  • Parche de 20 μg/h: Libera 20 microgramos por hora durante 7 días 1

Parches de Estradiol (Terapia Hormonal)

  • Parche de 50 mcg/24h: Libera aproximadamente 2.08 microgramos por hora 2
  • Parche de 100 mcg/24h: Libera aproximadamente 4.17 microgramos por hora 2, 3
  • Parche de 200 mcg/24h: Libera aproximadamente 8.33 microgramos por hora 2

Parches de Testosterona

  • Parche de 2 mg/24h: Libera aproximadamente 83 microgramos por hora 4
  • Parche de 4 mg/24h: Libera aproximadamente 167 microgramos por hora 4

Principios Farmacocinéticos de los Parches Transdérmicos

Los parches transdérmicos proporcionan liberación continua y sostenida del fármaco, resultando en concentraciones plasmáticas relativamente constantes durante todo el intervalo de dosificación. 1

  • La liberación es constante y predecible a lo largo de la duración especificada del parche 5, 6
  • Los parches de buprenorfina mantienen niveles estables durante 7 días completos 1
  • Los parches de estradiol requieren cambio cada 3-4 días (dos veces por semana) o semanalmente según la marca 2, 3

Advertencia Clínica Crítica

Si está preguntando sobre un parche específico de "20 mg", debe verificar la etiqueta del producto para confirmar si se refiere a 20 μg/h (microgramos por hora) o 20 mg/24h (miligramos en 24 horas), ya que esta diferencia es de 1000 veces en magnitud. 5, 6

References

2
Guideline

Estradiol Hormone Replacement Therapy Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

3
Guideline

Transdermal Estrogen Patch Application Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

4
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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