From the Research
There are no significant contraindications between tadalafil and fenofibrate when taken together, and they can generally be used concurrently without major drug interactions. However, both medications can potentially affect blood pressure, so patients should monitor for symptoms of hypotension such as dizziness or lightheadedness, especially when starting the combination. Tadalafil is a phosphodiesterase-5 inhibitor used for erectile dysfunction or benign prostatic hyperplasia, while fenofibrate is a fibric acid derivative used to lower triglycerides and cholesterol.
Key Considerations
- Patients with underlying cardiovascular disease should exercise caution and consult their healthcare provider before using this combination, as tadalafil can cause vasodilation and may enhance the hypotensive effects of other medications 1.
- Additionally, both medications are metabolized by the liver, so patients with hepatic impairment should use this combination with caution and possibly at reduced doses.
- Regular monitoring of liver function tests would be prudent when using these medications together.
Evidence Summary
The most recent and highest quality study, published in 2022, found that tadalafil was associated with an increase in hypotension-related treatment-emergent adverse events only in the erectile dysfunction as-needed group not receiving any concomitant antihypertensive medications, but no significant difference was reported between placebo and tadalafil in the groups of patients receiving ≥1 antihypertensive medication 1.
Clinical Implications
Based on the available evidence, the combination of tadalafil and fenofibrate can be used safely in most patients, but caution is advised in patients with underlying cardiovascular disease or hepatic impairment. Patients should be monitored for symptoms of hypotension and liver function tests should be regularly checked.