Mounjaro (Tirzepatide) Storage Requirements
Yes, Mounjaro (tirzepatide) must be refrigerated before first use, but can be stored at room temperature for up to 21 days after opening.
Storage Before First Use
- Unopened Mounjaro pens must be stored in the refrigerator at 2°C to 8°C (36°F to 46°F) until the expiration date 1, 2
- Keep the pen in its original carton to protect from light 2
- Do not freeze Mounjaro—if frozen, discard the pen even if it has thawed 2
Storage After First Use
- Once you start using a Mounjaro pen, you may store it in the refrigerator OR at room temperature up to 30°C (86°F) for up to 21 days 2
- After 21 days at room temperature, discard the pen even if medication remains 2
- Continue protecting from light and do not freeze 2
Practical Considerations for Travel and Daily Use
- For patients who travel frequently or prefer not to refrigerate daily, storing the in-use pen at room temperature is acceptable for the 21-day window 2
- If you're using the pen weekly (standard dosing), one pen will last approximately 4 weeks, so refrigeration of the in-use pen is recommended to maintain stability throughout the month 1, 2
- Always check the medication before injection—discard if the solution appears cloudy, discolored, or contains particles 2
Common Storage Pitfalls to Avoid
- Do not store Mounjaro in the freezer compartment or directly against refrigerator cooling elements 2
- Do not leave the pen in direct sunlight or in hot environments like a car 2
- Do not store with the needle attached, as this can cause medication leakage or air bubbles 2
- Keep out of reach of children and pets 2