Can a patient with migraines take Nurtec (rimegepant) and Maxalt (rizatriptan) together?

Can Nurtec and Maxalt Be Taken Together?

Yes, Nurtec (rimegepant) and Maxalt (rizatriptan) can be used together in the same patient, but they should NOT be taken simultaneously for the same migraine attack. These medications serve complementary roles in migraine management—rizatriptan as an acute abortive therapy and rimegepant for either acute treatment or prevention—but combining them for a single attack offers no additional benefit and increases unnecessary medication exposure 1.

Clinical Approach to Using Both Medications

When to Use Each Medication

For acute migraine attacks:

• Use rizatriptan (Maxalt) as first-line acute therapy with strong evidence supporting its efficacy: 71% of patients achieve pain relief at 2 hours with the 10 mg dose versus 35% with placebo 2, 3
• Alternatively, use rimegepant (Nurtec) for acute treatment if triptans are contraindicated or poorly tolerated, though the recommendation strength is weaker 1
• Never take both medications for the same migraine attack—choose one or the other based on patient response patterns 1

For migraine prevention:

• Rimegepant can be used every other day for prevention while reserving rizatriptan for breakthrough acute attacks 4
• This represents the most rational combination strategy: rimegepant for prevention and rizatriptan for acute rescue 1

Frequency Limitations to Prevent Medication Overuse Headache

Critical dosing restrictions:

• Limit rizatriptan to no more than 2 days per week (maximum 30 mg per day, taken as 5-20 mg every 2 hours) 1, 5
• Limit total acute medication use to twice weekly to prevent medication-overuse headache, regardless of which agent is used 1
• If acute medications are needed more frequently, initiate preventive therapy with first-line options including propranolol, topiramate, or CGRP monoclonal antibodies 5

Safety Considerations

No Direct Drug Interaction

• There is no pharmacologic contraindication to having both medications available to the same patient 1
• The VA/DoD guidelines provide strong recommendations for rizatriptan and weak recommendations for rimegepant without noting any interaction concerns 1

Contraindications for Rizatriptan

Do not use rizatriptan in patients with:

• Uncontrolled hypertension or coronary artery disease 1
• Concurrent use with ergot-type medications or other triptans 1
• Concurrent MAOIs or within 2 weeks of MAOI discontinuation 1
• Concurrent propranolol (requires dose reduction to rizatriptan 5 mg) 1

Common Pitfalls to Avoid

• Do not "stack" medications by taking rimegepant after rizatriptan fails for the same attack—this increases cost and side effects without proven benefit 1
• Do not use rizatriptan for prevention—it is only indicated for acute treatment 5
• Monitor for medication overuse headache if either medication is used more than twice weekly 1, 5

Practical Algorithm

1. If migraines occur ≤8 days per month: Use rizatriptan 10 mg as needed for acute attacks (limit to 2 days/week) 1, 2

2. If migraines occur >8 days per month: Start rimegepant 75 mg every other day for prevention, with rizatriptan 10 mg available for breakthrough attacks 4, 1

3. If triptans are contraindicated: Use rimegepant 75 mg as the sole acute therapy 1, 4

4. If acute medications are needed >2 days per week despite preventive therapy: Escalate prevention with additional agents (propranolol, topiramate, or injectable CGRP monoclonal antibodies) 1, 5