How long will a subdermal implant (containing etonogestrel), such as Nexplanon (etonogestrel), remain effective in a female of reproductive age with no specified medical history if removed before its due date?

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Contraceptive Effectiveness After Early Removal

The etonogestrel implant (Nexplanon) remains fully effective for contraception up until the moment it is physically removed from the arm, regardless of whether removal occurs before the 3-year expiration date. 1, 2

Immediate Loss of Contraceptive Protection

Contraceptive effectiveness ceases immediately upon implant removal, with rapid return to fertility. 2, 3 The key clinical points are:

  • Fertility returns promptly after removal - pregnancy rates of 76-100% occur within 1 year after removal, identical to discontinuation of any other contraceptive method 3
  • No residual contraceptive effect exists once the implant is physically removed from the subdermal space 2, 3
  • Alternative contraception must be initiated immediately if pregnancy prevention is desired after removal 1

Duration of Effectiveness While In Place

The implant maintains contraceptive efficacy throughout its approved duration:

  • Standard FDA-approved duration is 3 years for the etonogestrel implant 1, 4, 2
  • Failure rate remains <1% throughout the entire 3-year period with typical use 1
  • Contraceptive mechanism (ovulation suppression) continues uninterrupted until physical removal 2

Extended Use Beyond 3 Years

Emerging evidence suggests effectiveness may extend beyond the approved timeframe:

  • Research demonstrates documented effectiveness for up to 5 years with no pregnancies in extended use studies 5
  • One case report showed detectable serum etonogestrel levels persisting 6 years after insertion, though this is not recommended practice 5
  • However, removal by the end of the third year remains the official recommendation 2

Critical Clinical Pitfall

The question "how long will an implant be effective if removed before its due date" reflects a fundamental misunderstanding. The implant does not have residual effectiveness after removal - it works only while physically present in the body. If removed at 1 year, 2 years, or 2.9 years, contraceptive protection stops immediately at the moment of removal, not at some future "due date." 2, 3

Backup Contraception Requirements After Removal

If continuing contraception is desired:

  • Start alternative method immediately at the time of removal or before removal if switching methods 1
  • When inserting a new implant immediately after removal, no backup contraception is needed 1
  • When switching to other hormonal methods, follow standard initiation protocols with 7 days of backup contraception if not inserted within 5 days of menstrual bleeding 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Nexplanon Implantation Procedure

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Use of etonogestrel implant beyond approved duration: prolonged contraceptive effectiveness.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2018

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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