What is the best urea-based emollient for treating atopic dermatitis (eczema)?

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Last updated: April 12, 2025 • View editorial policy

From the Research

For eczema, a urea-containing emollient with 10% urea is the most effective option, as it has been shown to significantly improve symptoms and quality of life in patients with chronic eczematous dermatitis of the hands 1. This is because urea has dual benefits: it's a humectant that draws moisture into the skin and a mild keratolytic that gently exfoliates dead skin cells, reducing scaling and roughness. Some key points to consider when using urea emollients for eczema include:

  • Applying the emollient to affected areas 2-3 times daily, especially after bathing while skin is still slightly damp to lock in moisture
  • Using a urea concentration of 10% for severe cases, as it has been shown to be effective in improving symptoms and quality of life 1
  • Considering other excellent options, such as CeraVe Psoriasis Moisturizing Cream (contains 2% urea) for milder cases
  • Being consistent with application and continuing to use the emollient even when symptoms improve to maintain skin health
  • Consulting a dermatologist for prescription options if the eczema is severe or doesn't respond to these products within 2-3 weeks It's also worth noting that urea is a safe and effective dermatologic therapy with wide-ranging clinical utility and minimal, non-systemic side effects, making it a great option for patients with eczema 2.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.