From the Research
Eliquis (apixaban) should not be used alongside Voltaren gel (diclofenac sodium topical gel) without medical supervision, as this combination may increase the risk of bleeding due to the anticoagulant effects of apixaban and the anti-inflammatory effects of diclofenac sodium topical gel. While these medications can generally be used together, caution is warranted as both can affect blood clotting through different mechanisms. Eliquis is an anticoagulant that prevents blood clots by inhibiting Factor Xa in the clotting cascade, as shown in a study published in 2013 1, which demonstrated its efficacy in reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Voltaren gel, on the other hand, is a topical NSAID that may slightly increase bleeding risk through its anti-inflammatory effects. The risk of interaction is relatively low because Voltaren gel is applied topically with minimal systemic absorption compared to oral NSAIDs. However, patients should monitor for unusual bleeding or bruising when using these medications together, as suggested by a study published in 2023 2, which highlighted the importance of patient education and awareness of potential interactions between over-the-counter products and apixaban. This combination might be particularly concerning for patients with additional bleeding risk factors such as advanced age, kidney disease, or use of other blood-thinning medications. Always inform your healthcare provider about all medications you're taking, including topical preparations, to ensure safe use of these medications together.
Some key points to consider when using Eliquis alongside Voltaren gel include:
- Monitoring for unusual bleeding or bruising
- Informing your healthcare provider about all medications, including topical preparations
- Being aware of potential interactions between over-the-counter products and apixaban
- Considering alternative treatments or adjusting the dosage of either medication to minimize the risk of bleeding
- Regularly reviewing and updating your medication list to ensure safe use of these medications together, as recommended by a study published in 2015 3, which compared the efficacy and safety of novel oral anticoagulants in patients with atrial fibrillation.