From the Research
Diagnostic Criteria for Sarcoidosis Exacerbation
The diagnostic criteria for sarcoidosis exacerbation are not explicitly stated in the provided studies. However, the studies discuss the diagnostic approach to sarcoidosis in general.
- The diagnosis of sarcoidosis is based on a compatible clinical presentation, histologic findings of granulomatous inflammation, exclusion of alternative diseases, and evidence of systemic involvement 1.
- A presumptive diagnosis may be acceptable in special conditions, but histological confirmation is usually required 2.
- The American Thoracic Society (ATS) recommends that the diagnosis of sarcoidosis be based on consistent, adequate clinical presentation, demonstration of granulomatous lesions in pathomorphological examination, and exclusion of alternative causes of granulomatous disease 3.
- The diagnosis is not standardized, but it is based on three major criteria: a compatible clinical and/or radiological presentation, histological evidence of non-necrotizing granulomatous inflammation, and exclusion of alternative causes of granulomatous disease 4.
Monitoring and Follow-up
Regular follow-up is necessary to monitor changes in the disease, including extension, progression, remissions, flare-ups, and complications 5.
- A multidisciplinary approach is recommended for best outcomes, as sarcoidosis is a systemic disease that can affect multiple organs 5, 2.
- Effective regular follow-up is necessary to monitor changes in the disease and to establish whether the patient is likely to benefit from treatment 5.
Clinical Presentation and Diagnosis
Sarcoidosis can affect any organ, with intrathoracic involvement occurring in 90% of patients 4.
- Certain clinical features are considered to be highly specific of the disease and do not require histological confirmation, such as Löfgren's syndrome, lupus pernio, and Heerfordt's syndrome 4.
- New diagnostic guidelines have been published, including specific clinical criteria for the diagnosis of cardiac, neurological, and ocular sarcoidosis 4.