What is a syndesmotic injury?

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Last updated: January 13, 2026View editorial policy

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What is a Syndesmotic Injury?

A syndesmotic injury is damage to the ligaments that connect the distal tibia and fibula, forming the distal tibiofibular joint—often called a "high ankle sprain" because these ligaments sit above the standard ankle joint ligaments. 1, 2

Anatomical Structure

The syndesmosis is a fibrous joint comprised of four key ligaments that stabilize the distal tibia and fibula 3:

  • Anterior tibiofibular ligament (most commonly injured) 4
  • Posterior tibiofibular ligament 3
  • Transverse ligament 3
  • Interosseous ligament 3

These ligaments maintain the integrity of the ankle mortise, which is critical for normal weight-bearing and ankle movement 2, 3.

Clinical Significance

Even 1 mm of widening in the ankle mortise decreases the tibiotalar joint contact area by 42%, leading to instability and early osteoarthritis if untreated. 3 This makes accurate diagnosis and appropriate treatment essential for preventing long-term disability 1, 2.

Mechanism of Injury

Syndesmotic injuries typically occur through 2:

  • External rotation of the foot on the leg (most common mechanism) 2
  • Excessive dorsiflexion 2
  • High-energy rotational forces during activities like skiing, football, soccer, and sports played on artificial turf 2

Injury Patterns

Syndesmotic injuries can present in two ways 1, 5:

  • Isolated ligamentous injury (1-11% of all ankle sprains) 3
  • Combined with ankle fractures (50% of Weber B fractures and nearly all Weber C fractures) 3

Grading System

MRI is the reference standard for grading syndesmotic injuries (Grade 1,2, or 3), which is critical for treatment planning and return-to-sport decisions, particularly in athletes. 4, 6

  • Grade 1: Mild sprain without instability 5
  • Grade 2: Moderate sprain with partial ligament tears 5
  • Grade 3: Complete ligament rupture with instability 5

Why This Injury Matters

Syndesmotic injuries are frequently misdiagnosed and can cause 1, 2:

  • Prolonged functional limitations extending beyond typical ankle sprains 1
  • Persistent ankle instability (40% of patients still symptomatic at 6 months) 3
  • Long-term ankle dysfunction if not properly identified and treated 1
  • Early post-traumatic osteoarthritis from chronic mortise widening 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Management of Syndesmosis Injury: A Narrative Review.

Orthopedic research and reviews, 2022

Guideline

Consequences of Untreated Syndesmotic Injury in Ankle Fractures

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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