From the Research
Skin peeling on the hands is not a typical symptom of infectious mononucleosis (mono), and if experienced, it is likely unrelated or a reaction to medications, such as antibiotics or NSAIDs, as suggested by studies like 1. Infectious mononucleosis, caused primarily by the Epstein-Barr virus, usually presents with symptoms like severe fatigue, sore throat, fever, swollen lymph nodes, and sometimes an enlarged spleen or liver, as outlined in recent reviews like 2 and 3. For the peeling skin, using gentle, fragrance-free moisturizers regularly and avoiding harsh soaps or hot water, which can worsen dryness, is recommended. If the peeling is severe, painful, or accompanied by a rash, consulting a healthcare provider is necessary, as this could indicate a separate condition requiring treatment, as discussed in 4. While recovering from mono, focusing on rest, hydration, and avoiding strenuous activities, especially contact sports, for at least 4-6 weeks to prevent potential spleen rupture, is crucial, as advised in 2 and 3. The skin peeling should resolve on its own with proper skin care, but persistent symptoms warrant medical attention. Key aspects of managing infectious mononucleosis include supportive care, as there is no specific treatment, and being aware of potential complications, as highlighted in 5. Given the information from the most recent and highest quality studies, such as 2 and 3, the approach to skin peeling in the context of infectious mononucleosis should prioritize gentle skin care and monitoring for any signs of separate conditions that may require medical intervention.