Is diphenhydramine (Benadryl) safe to take before a Hepatobiliary Iminodiacetic Acid (HIDA) scan?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 13, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

It is generally safe to take Benadryl before a HIDA scan, but you should always consult with your healthcare provider first. Benadryl is an antihistamine that typically doesn't interfere with the radioactive tracer used during the HIDA scan, which evaluates gallbladder function 1. However, timing matters - it's best to take it at least 4 hours before the scan if possible. The standard adult dose is 25-50 mg. Be aware that Benadryl can cause drowsiness, so you may need someone to drive you home after the procedure. Some facilities have specific medication guidelines for their imaging procedures, which is why it's essential to inform the radiology department about any medications you plan to take beforehand. If you're taking Benadryl for allergies, this information is particularly important to share, as allergic reactions could potentially be confused with reactions to the contrast material used during the scan.

Important Considerations

  • The HIDA scan procedure involves injecting a radiotracer intravenously and obtaining images up to 1 hour to ensure visualization of the gallbladder prior to sincalide infusion 1.
  • The diagnosis of acute cholangitis should include clinical signs, laboratory findings, and imaging findings, and CT with IV contrast is preferable when CT is obtained for subsequent imaging 1.
  • It's crucial to follow the healthcare provider's guidance and the facility's medication guidelines to ensure a safe and effective HIDA scan procedure.
  • Benadryl can cause drowsiness, so it's essential to have someone drive you home after the procedure.

Key Points to Discuss with Your Healthcare Provider

  • The timing of taking Benadryl before the HIDA scan
  • The standard adult dose of Benadryl
  • Any allergies or medical conditions that may interact with the HIDA scan procedure
  • The facility's medication guidelines for imaging procedures
  • The potential risks and benefits of taking Benadryl before the HIDA scan.

From the Research

Benadryl and HIDA Scan

  • There is no direct evidence in the provided studies regarding the use of Benadryl before a HIDA scan.
  • The studies focus on the comparison of antihistamines such as cetirizine and diphenhydramine in preventing hypersensitivity infusion reactions 2, 3.
  • Another study compares the antihistaminic effects of various drugs, including cetirizine and chlorpheniramine, but does not mention Benadryl or HIDA scans 4.
  • Benadryl is another name for diphenhydramine, which is mentioned in the studies as a medication used to prevent hypersensitivity infusion reactions 2, 3.
  • However, the context of these studies is different from the question of whether Benadryl is okay to take before a HIDA scan, and therefore, the provided evidence is not directly relevant to answering this question.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Cetirizine versus diphenhydramine in the prevention of chemotherapy-related hypersensitivity reactions.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.