What is the treatment for Ulcerative Colitis (UC) with a flare-up induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

From the Research

Treatment for Ulcerative Colitis (UC) with a flare-up induced by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

• The treatment for UC with a flare-up induced by NSAIDs is not directly addressed in the provided studies. However, the studies discuss the general treatment approaches for UC flare-ups.
• According to 1, mild-to-moderate UC can be managed with aminosalicylates, mesalamine, and topical corticosteroids, while moderate-to-severe UC may require oral or intravenous corticosteroids.
• 2 suggests that oral 5-aminosalicylates (5-ASAs) and systemic steroids are the mainstay of treatment in patients with new-onset ulcerative colitis.
• 3 reports that the majority of respondents with UC used 5-ASAs or corticosteroids as maintenance medications and increased the dose or added corticosteroids to control flares in the short term.
• 4 states that systemic corticosteroids should be used in UC patients with moderate to severe disease and in patients who failed to respond to 5-ASA compounds.
• 5 discusses the use of mesalazine as a maintenance treatment after a first course of corticosteroids and identifies predictive factors of relapse and colectomy.

Treatment Options

• Aminosalicylates (e.g., mesalamine) 1, 2, 4
• Topical corticosteroids 1
• Oral corticosteroids 1, 2, 3, 4
• Immunomodulators (e.g., azathioprine, methotrexate, cyclosporine) 4
• Mesalazine as a maintenance treatment after a first course of corticosteroids 5

Considerations

• Disease severity and extent should be taken into account when determining the course of therapy 1.
• Treatment intensification may be warranted if expected improvement goals are not reached 1.
• Medication adherence should be assessed and promoted to minimize the risk of relapse 5.