From the Guidelines
The normal range of prolactin in males is not explicitly stated in the provided evidence, but based on general medical knowledge, it is typically considered to be between 86-324 uIU/mL (4-15 ng/mL) 1. This range may vary slightly between different laboratories due to differences in testing methods and reference standards. Prolactin is a hormone primarily produced by the anterior pituitary gland that plays a key role in various bodily functions. In men, elevated prolactin levels (hyperprolactinemia) can cause several symptoms, and when interpreting prolactin results, it's essential to consider that levels can be temporarily increased by various factors. Some key points to consider when evaluating prolactin levels include:
- The potential for hyperprolactinemia due to certain medical conditions, such as primary hypothyroidism, chronic kidney disease, and severe liver disease 1.
- The impact of medications on prolactin levels, as they can stimulate prolactin production or antagonize inhibitory dopaminergic tone 1.
- The importance of considering the clinical context and potential confounding factors when interpreting prolactin results. It is crucial to consult the latest and highest-quality studies for the most accurate and up-to-date information on prolactin levels and their interpretation, as the provided evidence does not directly address the normal range of prolactin in males.
From the Research
Normal Range of Prolactin in Males
The normal range of prolactin in males is measured in uIU/mL or mIU/L, with various studies providing reference ranges.
- According to the study 2, the reference range for serum total prolactin in males is 58-419 mIU/L.
- The same study 2 also provides a reference range for monomeric prolactin in males, which is 32-309 mIU/L.
- It is essential to note that prolactin levels can vary due to physiological causes, including age and sex, as mentioned in the study 3.
- The study 3 highlights the importance of establishing reference intervals for serum prolactin concentrations, considering analytical and clinical factors.
Conversion to uIU/mL
Since 1 uIU/mL is equivalent to 1 mIU/L, the reference ranges provided in the studies can be directly applied to uIU/mL.
- The reference range for serum total prolactin in males is 58-419 uIU/mL.
- The reference range for monomeric prolactin in males is 32-309 uIU/mL.
Clinical Considerations
It is crucial to consider the clinical context and potential interferences, such as macroprolactinemia, when interpreting prolactin levels, as discussed in the studies 2 and 3.