From the FDA Drug Label
Drugs that Interfere with Enterohepatic Recirculation Clinical Impact Concomitant use with drugs that directly interfere with enterohepatic recirculation, or indirectly interfere with enterohepatic recirculation by altering the gastrointestinal flora, can decrease MPA systemic exposure [see Clinical Pharmacology (12. 3)] , which may reduce mycophenolate mofetil efficacy. Prevention or Management Monitor patients for alterations in efficacy or mycophenolate mofetil related adverse reactions when these drugs are co-administered with mycophenolate mofetil. Examples Trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials
The interaction between Cellcept (Mycophenolate Mofetil) and Augmentin (Amoxicillin-Clavulanate) is that concomitant use may decrease MPA systemic exposure, which may reduce mycophenolate mofetil efficacy, as Augmentin is a penicillin class of antimicrobial that can alter gastrointestinal flora and interfere with enterohepatic recirculation.
- Key Points: + Concomitant use may decrease MPA systemic exposure + Monitor patients for alterations in efficacy or mycophenolate mofetil related adverse reactions + Augmentin is a penicillin class of antimicrobial that can interfere with enterohepatic recirculation 1
From the Research
Interaction between Cellcept (Mycophenolate Mofetil) and Augmentin (Amoxicillin-Clavulanate)
There are no research papers provided to directly assist in answering the question about the interaction between Cellcept (Mycophenolate Mofetil) and Augmentin (Amoxicillin-Clavulanate).
Available Information on Cellcept
- Cellcept (Mycophenolate Mofetil) is an immunosuppressive drug that inhibits inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the purine synthesis pathway of lymphocytes 2.
- It has a selective lymphocyte suppression effect, leading to a reduction in the incidence of rejection in renal allograft patients 2.
- The drug has been shown to be effective in preventing allograft rejection and has a well-established efficacy in renal transplantation 3, 4, 5, 6.
- Common side effects of Cellcept include hematologic and infectious adverse reactions 4, as well as gastrointestinal and hematopoietic system effects 2.
Lack of Information on Interaction with Augmentin
- There is no information provided in the studies about the interaction between Cellcept (Mycophenolate Mofetil) and Augmentin (Amoxicillin-Clavulanate).
- The studies primarily focus on the efficacy and safety of Cellcept in renal transplant patients, as well as its mechanisms of action and comparison with generic formulations 3, 4, 5, 2, 6.