From the Guidelines
The recommended dose and frequency of Lactobacillus (probiotic) supplementation is not strictly established, but most studies suggest a dose range of 1-10 billion CFU (Colony-Forming Units) per day, with some studies using higher or lower doses.
- The optimal dose and frequency may vary depending on the specific strain of Lactobacillus, the individual's health status, and the desired outcome.
- Some studies have used Lactobacillus acidophilus at a dose of 1-2 billion CFU per day, while others have used Lactobacillus rhamnosus at a dose of 1-10 billion CFU per day 1.
- A study on premature infants used Lactobacillus reuteri DSM 17938 at a dose of 1.25 × 10^8 CFU per day, which was associated with improved gut microbiome and infant growth 1.
- For irritable bowel syndrome (IBS), a meta-analysis suggested that Lactobacillus supplementation at a dose of 1-10 billion CFU per day for up to 12 weeks may be effective in improving symptoms 1.
- It is essential to note that the quality and efficacy of probiotics can vary widely depending on the manufacturer, and more research is needed to establish standardized dosing and treatment protocols.
- In clinical practice, the choice of probiotic strain and dose should be individualized based on the patient's specific needs and health status, and under the guidance of a healthcare professional.
From the Research
Recommended Dose and Frequency of Lactobacillus Supplementation
The recommended dose and frequency of Lactobacillus supplementation vary depending on the specific strain, population, and health outcome being targeted.
- The dose of Lactobacillus supplementation ranged from 10^5 to 10^12 CFU/dose in various studies 2.
- A daily dose of ≥ 10^9 CFU of Lactobacillus acidophilus was associated with a reduced duration of diarrhea in children with acute gastroenteritis 3.
- A higher dose and longer duration of Lactobacillus supplementation may contribute to a positive impact on H. pylori eradication in children 4.
- The frequency of Lactobacillus supplementation also varied, with intervention lengths ranging from one to more than 6 months 2.
Strain-Specific Recommendations
Different strains of Lactobacillus may have different effects on health outcomes, and the recommended dose and frequency may vary depending on the specific strain.
- Lactobacillus rhamnosus GG supplementation, via food and non-food matrices, has been shown to promote health in infants and children 2.
- Lactobacillus acidophilus supplementation has been shown to reduce the duration of diarrhea in children with acute gastroenteritis, particularly when used at a daily dose ≥ 10^9 CFU 3.
Considerations for Supplementation
When considering Lactobacillus supplementation, it is essential to take into account the specific health outcome being targeted, as well as the population and individual characteristics.