What is the recommended dose and frequency of Robaxin (Methocarbamol)?

From the Guidelines

The recommended dose and frequency of Robaxin (Methocarbamol) is 1000-1500 mg every 4-6 hours, with a maximum dose of ≤ 4 g/day [@\1@].

Dosing Regimens

• The dosing regimens for Methocarbamol vary, but the most commonly recommended dose is 400-800 mg IV every 6 hours or 400 mg PO every 4 hours [@\1@].
• For oral administration, the starting dose is typically 100 mg PO three times daily, with a maintenance dose of 900-3600 mg/day in 3 divided doses [@\1@].
• The maximum dose for IV administration is ≤ 4 g/day, while the maximum dose for PO administration is ≤ 2.4 g/day or ≤ 1200 mg/day for some regimens [@\1@].

Administration

• Methocarbamol can be administered orally or intravenously, with IV administration typically involving infusion over > 30 minutes [@\1@].
• The choice of administration route and dosing regimen may depend on the individual patient's needs and medical condition.

From the FDA Drug Label

DOSAGE AND ADMINISTRATION For Intravenous and Intramuscular Use Only. Total adult dosage should not exceed 30 mL (3 vials) a day for more than 3 consecutive days except in the treatment of tetanus. For the relief of symptoms of moderate degree, one dose of 1 gram (one 10 mL vial) may be adequate. For the severest cases or in postoperative conditions in which oral administration is not feasible, additional doses of 1 gram may be repeated every 8 hours up to a maximum of 3 g/day for no more than 3 consecutive days.

The recommended dose and frequency of Robaxin (Methocarbamol) is:

• 1 gram (one 10 mL vial) for moderate symptoms, which may be adequate as a single dose
• 1 gram repeated every 8 hours, up to a maximum of 3 g/day for no more than 3 consecutive days for severe cases or postoperative conditions 1

From the Research

Dosage and Frequency of Robaxin (Methocarbamol)

• The recommended dose and frequency of Robaxin (Methocarbamol) are not explicitly stated in the provided studies 2, 3, 4, 5, 6.
• However, the studies suggest that Methocarbamol is typically administered orally, with treatment durations ranging from a few days to several weeks 3, 4.
• In one study, patients received Methocarbamol for up to 8 days, with treatment discontinued as soon as a pain-free state was achieved 3.
• Another study reported that patients received Methocarbamol for 4 weeks, with significant improvements in pain intensity, pain-related disability, and quality of life 4.
• It is essential to note that the dosage and frequency of Methocarbamol may vary depending on the individual patient's condition and response to treatment, and should be determined by a healthcare professional 2, 3, 4, 5, 6.

Administration and Warnings

• Methocarbamol can be administered orally or intravenously, but the intravenous form contains the excipient polyethylene glycol (PEG), which has been implicated in metabolic acidosis and nephrotoxicity 5.
• The combination of Methocarbamol and ethanol is contraindicated due to the risk of combined central nervous system depression 6.
• Patients with renal impairment should be cautious when using intravenous Methocarbamol, as the warning for PEG-associated adverse drug events may be relevant 5.