What are the brand names for nitrofurantoin in an otherwise healthy adult patient with an uncomplicated urinary tract infection (UTI)?

Nitrofurantoin Brand Names

Nitrofurantoin is available as macrocrystals formulation, which is the generic name itself rather than a specific brand name. 1

Available Formulations

The FDA-approved formulation is:

• Nitrofurantoin (macrocrystals) - This is the standard oral formulation used for uncomplicated urinary tract infections 1

Clinical Context for UTI Treatment

While you asked about brand names, it's important to note that nitrofurantoin is widely recommended as a first-line treatment for uncomplicated UTIs in otherwise healthy adult women 2, 3:

• Standard dosing: 100 mg orally every 6 hours (four times daily) for uncomplicated cystitis 2
• Alternative dosing: 100 mg twice daily for 5 days is also recommended by European guidelines 3
• Treatment duration: 5 days is the recommended duration for acute uncomplicated cystitis 2

Key Clinical Advantages

Nitrofurantoin demonstrates several advantages that make it a preferred first-line agent 3, 4:

• Superior microbiological cure rates compared to fosfomycin 3
• Low resistance rates - maintains excellent activity against E. coli despite over 60 years of use 5, 6
• Minimal collateral damage to intestinal flora compared to fluoroquinolones and cephalosporins 3

Important Contraindications

Do not use nitrofurantoin in patients with 5:

• Renal impairment of any degree
• Last three months of pregnancy
• Pyelonephritis or upper UTIs (insufficient tissue penetration) 2, 4