What is the diagnosis for a 17-year-old female patient with Post-Traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD), and Substance Use Disorder (SUD) after alleged sexual abuse?

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Diagnosis: Complex Post-Traumatic Stress Disorder (Complex PTSD)

This 17-year-old female patient meets diagnostic criteria for Complex Post-Traumatic Stress Disorder (Complex PTSD), characterized by core PTSD symptoms plus emotion dysregulation, interpersonal problems, negative self-concept, and substance use disorder—all stemming from prolonged sexual trauma. 1

Clinical Presentation Analysis

The triad of PTSD, Major Depressive Disorder, and Substance Use Disorder following sexual abuse represents the classic presentation of Complex PTSD rather than three separate diagnoses. 1, 2

Core PTSD Features Present

  • Re-experiencing symptoms: Intrusive thoughts, flashbacks, or psychological distress related to the sexual abuse 2
  • Avoidance behaviors: Active avoidance of trauma reminders 2
  • Hyperarousal: Sleep disturbance, hypervigilance, irritability 2
  • Negative cognitions: Persistent negative beliefs about self and the world 2

Complex PTSD-Specific Features

  • Emotion dysregulation: The depressive symptoms represent difficulty modulating emotional responses to trauma-related stimuli 1
  • Negative self-concept: Self-blame, shame, and feelings of being damaged—common in sexual assault survivors 3, 4
  • Interpersonal difficulties: Violated trust and relationship problems following sexual trauma 3, 4
  • Substance use as coping: The SUD represents maladaptive attempts to manage overwhelming trauma-related emotions 3, 5

Why This is Complex PTSD Rather Than Separate Diagnoses

Approximately 50% of sexual assault survivors develop PTSD, and those with childhood/adolescent sexual trauma commonly present with this constellation of symptoms. 3 The evidence demonstrates that patients with comorbid PTSD and depression following trauma differ clinically and biologically from those with either condition alone, supporting the Complex PTSD conceptualization. 6

Key Diagnostic Indicators

  • Trauma timing: Sexual abuse during adolescence (developmental period) increases risk for complex presentation 3, 7
  • High comorbidity pattern: PTSD patients have elevated rates of depression (present here as MDD) and substance use disorders (present here as SUD) 2, 5
  • Functional impairment: Complex PTSD is characterized by greater symptom severity and higher impairment in social/occupational functioning compared to PTSD alone 6

Critical Assessment Requirements

Immediate Safety Evaluation

Screen immediately for suicidal ideation, self-harm behaviors, and homicidal ideation, as sexual assault survivors have significantly elevated rates of depression, suicidal ideation/attempts, and self-mutilation. 3, 4 If suicidal or homicidal ideation is present, this requires immediate intervention with an experienced mental health professional. 3, 4

Trauma History Details to Obtain

  • Age at first trauma (earlier age predicts worse SUD outcomes) 7
  • Number of traumatic events (multiple traumas are common, with mean age of first trauma around 14 years in SUD populations) 5
  • Specific trauma types (sexual assault carries higher PTSD risk than other trauma types) 3
  • History of self-harm or suicide attempts (37% of trauma patients with SUD have this history) 5

Associated Risk Behaviors to Assess

  • Poor contraception use 3
  • Risky sexual behaviors and higher number of pregnancies/abortions 3
  • Higher rates of STIs 3
  • Eating disorders 3, 4
  • Self-mutilation 3, 4

Common Diagnostic Pitfalls

Do not diagnose three separate psychiatric disorders (PTSD + MDD + SUD) when the clinical picture represents Complex PTSD. The depression and substance use are manifestations of the underlying trauma pathology, not independent conditions. 1, 6

Do not delay psychiatric assessment if concerning symptoms are present. Evidence of suicidal or homicidal ideation requires immediate attention with an experienced mental health professional. 3, 4

Do not assume the patient contributed to the assault or was confused about consent. Adolescent victims commonly experience self-blame and confusion about whether the incident was forced or consensual, but this represents a predictable trauma response, not reality. 3, 8

References

Guideline

Treatment of Post-Traumatic Stress Disorder (PTSD)

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Pregnancy as a Trauma Trigger in Sexual Assault Survivors

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Trauma-Informed Care for Survivors of Unhealthy Relationships

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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